Abstract:
Free-radical reactions of glycero- and sphingolipids occurring in their polar moiety (fragmentation) and in their hydrophobic residue (peroxidation) under the action of reactive oxygen species are considered. The main attention is focused on free-radical fragmentation; its mechanism and regularities are discussed. Lipid peroxidation has been shown to modify the residues of polyunsaturated fatty acids, while the free-radical fragmentation results in the cleavage of ester, O-glycosidic and amide bonds in lipid molecules to give glycerophosphatides, ceramides and fatty acid amides functioning as secondary messengers in biosystems. The bibliography includes 132 references.
Received: 22.12.2010
Bibliographic databases:
Document Type:
Article
Language: English
Original paper language: Russian
Citation:
I. L. Yurkova, “Free-radical reactions of glycerolipids and sphingolipids”, Usp. Khim., 81:2 (2012), 175–190; Russian Chem. Reviews, 81:2 (2012), 175–190
Linking options:
https://www.mathnet.ru/eng/rcr9
https://doi.org/10.1070/RC2012v081n02ABEH004205
https://www.mathnet.ru/eng/rcr/v81/i2/p175
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