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Matematicheskaya Biologiya i Bioinformatika, 2019, Volume 14, Issue 1, Pages 220–232
DOI: https://doi.org/10.17537/2019.14.220
(Mi mbb381)
 

This article is cited in 1 scientific paper (total in 1 paper)

Bioinformatics

Using probabilistic neural networks to predict the localization of proteins in cell compartments

P. S. Nazinab, P. M. Gotovtseva

a National Research Center «Kurchatov Institute», Biotechnology and bioenergy department, Moscow, Russia
b Moscow Institute of Physics and Technology (State University), Moscow, Russia
References:
Abstract: This paper describes the use of probabilistic neural networks to solve problems of bioinformatics by the example of determining the localization of proteins according to their primary structure. The data used are sets of characteristics of amino acid sequences of proteins, obtained by various software tools aimed at finding specific signal sequences, as well as data on where these proteins are localized in cells of two microorganisms – E. coli and S. cerevisiae. The data source is the UCI Machine Learning Repository (http://archive.ics.uci.edu/ml/datasets). The possibility of using probabilistic neural networks to solve this problem is shown, since the classification accuracy of 57.5 % and 85.0 % for yeast and for bacterial cells is obtained, respectively. The obtained indicators of the accuracy of the classification of the data used exceed those that, according to the literature, were achieved with the use of other recognition methods. It is noted that a high learning rate and the possibility of modification make probabilistic neural networks a promising tool for analyzing bioinformatics data.
Key words: probabilistic neural networks, localization of protein, data classification, machine learning, databases.
Funding agency Grant number
Ministry of Education and Science of the Russian Federation 14.601.21.0017
Received 29.11.2018, 17.05.2019, Published 23.05.2019
Document Type: Article
UDC: 004.891.3
Language: Russian
Citation: P. S. Nazin, P. M. Gotovtsev, “Using probabilistic neural networks to predict the localization of proteins in cell compartments”, Mat. Biolog. Bioinform., 14:1 (2019), 220–232
Citation in format AMSBIB
\Bibitem{NazGot19}
\by P.~S.~Nazin, P.~M.~Gotovtsev
\paper Using probabilistic neural networks to predict the localization of proteins in cell compartments
\jour Mat. Biolog. Bioinform.
\yr 2019
\vol 14
\issue 1
\pages 220--232
\mathnet{http://mi.mathnet.ru/mbb381}
\crossref{https://doi.org/10.17537/2019.14.220}
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  • This publication is cited in the following 1 articles:
    Citing articles in Google Scholar: Russian citations, English citations
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