Abstract:
Functional analysis of 167 genes overexpressed in Krebs-2 tumor initiating cells was performed. Genes were assigned to the three functional groups that determine the malignant phenotype of cancer cells. These groups represent the following features of tumor cells: proliferative self-sufficiency, invasive growth and metastasis, and multiple drug resistance. Malignancy of cancer stem cells was found to be provided by the same genes that provide the stemness of normal pluri-/multipotent stem cells. These results suggest that the malignancy is just the ability to maintain the stem cell specific genes expression profile, and, as a consequence, the stemness itself regardless of the controlling effect of stem niches.
Key words:
malignancy, cancer stem cells, pluripotency, stem cell niche, genes-markers of stemness.
Citation:
Ya. R. Efremov, A. S. Proskurina, E. A. Potter, E. V. Dolgova, O. V. Efremova, N. A. Kolchanov, S. S. Bogachev, “Yin and yang of pluripotency: results of analysis of genes overexpressed in tumor-initiating cells of Krebs-2 ascites carcinoma”, Mat. Biolog. Bioinform., 14:1 (2019), 160–187
\Bibitem{EfrProPot19}
\by Ya.~R.~Efremov, A.~S.~Proskurina, E.~A.~Potter, E.~V.~Dolgova, O.~V.~Efremova, N.~A.~Kolchanov, S.~S.~Bogachev
\paper Yin and yang of pluripotency: results of analysis of genes overexpressed in tumor-initiating cells of Krebs-2 ascites carcinoma
\jour Mat. Biolog. Bioinform.
\yr 2019
\vol 14
\issue 1
\pages 160--187
\mathnet{http://mi.mathnet.ru/mbb378}
\crossref{https://doi.org/10.17537/2019.14.160}
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https://www.mathnet.ru/eng/mbb378
https://www.mathnet.ru/eng/mbb/v14/i1/p160
This publication is cited in the following 1 articles:
Ya. R. Efremov, A. S. Proskurina, E. A. Potter, E. V. Dolgova, O. V. Efremova, D. Yu. Oschepkov, N. A. Kolchanov, S. S. Bogachev, “Stvolovye rakovye kletki: “sluzhba spaseniya” dlya opukholei v usloviyakh generalizovannogo kletochnogo stressa”, Matem. biologiya i bioinform., 14:1 (2019), 306–326
Citation in format AMSBIB
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