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This article is cited in 1 scientific paper (total in 1 paper)
Bioinformatics
Yin and yang of pluripotency: results of analysis of genes overexpressed in tumor-initiating cells of Krebs-2 ascites carcinoma
Ya. R. Efremovab, A. S. Proskurinaa, E. A. Pottera, E. V. Dolgovaa, O. V. Efremovab, N. A. Kolchanova, S. S. Bogacheva a Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia
b Novosibirsk State University, Novosibirsk, Russia
Abstract:
Functional analysis of 167 genes overexpressed in Krebs-2 tumor initiating cells was performed. Genes were assigned to the three functional groups that determine the malignant phenotype of cancer cells. These groups represent the following features of tumor cells: proliferative self-sufficiency, invasive growth and metastasis, and multiple drug resistance. Malignancy of cancer stem cells was found to be provided by the same genes that provide the stemness of normal pluri-/multipotent stem cells. These results suggest that the malignancy is just the ability to maintain the stem cell specific genes expression profile, and, as a consequence, the stemness itself regardless of the controlling effect of stem niches.
Key words:
malignancy, cancer stem cells, pluripotency, stem cell niche, genes-markers of stemness.
Received 29.03.2019, Published 30.04.2019
Citation:
Ya. R. Efremov, A. S. Proskurina, E. A. Potter, E. V. Dolgova, O. V. Efremova, N. A. Kolchanov, S. S. Bogachev, “Yin and yang of pluripotency: results of analysis of genes overexpressed in tumor-initiating cells of Krebs-2 ascites carcinoma”, Mat. Biolog. Bioinform., 14:1 (2019), 160–187
Linking options:
https://www.mathnet.ru/eng/mbb378 https://www.mathnet.ru/eng/mbb/v14/i1/p160
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