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Matematicheskaya Biologiya i Bioinformatika, 2019, Volume 14, Issue 1, Pages 306–326
DOI: https://doi.org/10.17537/2019.14.306 (Mi mbb386) 		 
Bioinformatics

Cancer stem cells: “Emergency service” for tumors under generalized cellular stress

Ya. R. Efremovab, A. S. Proskurinaa, E. A. Pottera, E. V. Dolgovaa, O. V. Efremovab, D. Yu. Oshchepkova, N. A. Kolchanova, S. S. Bogacheva

a Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia
b Novosibirsk State University, Novosibirsk, Russia
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DOI: https://doi.org/10.17537/2019.14.306
Abstract: The analysis of conditions and possible mechanisms of activation of 96 genes providing a malignant/pluripotent phenotype of Krebs-2 cancer stem cells have been performed. Three stress factors combined into the single concept of “generalized cellular stress”, which are supposed to regulate the expression of these genes, are determined. Additionally, for these genes, the presence of binding sites for transcription factors that are being activated in response to factors of generalized cellular stress has been established. The data obtained suggest the existence of a mechanism for the de novo formation of a pluripotent/stem-like phenotype of tumor cells under conditions of generalized cellular stress.
Key words: cancer stem cell, TAMRA+ cells, induction of pluripotency, hypoxia, oxidative stress, xenobiotics, carcinogenesis.
Funding agency Grant number
Ministry of Education and Science of the Russian Federation 0324-2019-0042
Received 29.03.2019, Published 18.06.2019
Document Type: Article
UDC: 573.7, 57.016.4
Language: Russian
Citation: Ya. R. Efremov, A. S. Proskurina, E. A. Potter, E. V. Dolgova, O. V. Efremova, D. Yu. Oshchepkov, N. A. Kolchanov, S. S. Bogachev, “Cancer stem cells: “Emergency service” for tumors under generalized cellular stress”, Mat. Biolog. Bioinform., 14:1 (2019), 306–326
Citation in format AMSBIB
\Bibitem{EfrProPot19}
\by Ya.~R.~Efremov, A.~S.~Proskurina, E.~A.~Potter, E.~V.~Dolgova, O.~V.~Efremova, D.~Yu.~Oshchepkov, N.~A.~Kolchanov, S.~S.~Bogachev
\paper Cancer stem cells: ``Emergency service'' for tumors under generalized cellular stress
\jour Mat. Biolog. Bioinform.
\yr 2019
\vol 14
\issue 1
\pages 306--326
\mathnet{http://mi.mathnet.ru/mbb386}
\crossref{https://doi.org/10.17537/2019.14.306}
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