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Matematicheskaya Biologiya i Bioinformatika, 2019, Volume 14, Issue 1, Pages 233–256
DOI: https://doi.org/10.17537/2019.14.233
(Mi mbb382)
 

Information and Computer Technologies in Biology and Medicine

Mathematical modeling of the antihypertensive drugs action

I. N. Kiselevab, E. O. Kutumovaab, A. F. Kolpakovaab, G. I. Lifshitsc, F. A. Kolpakovab

a Institute of Computational Technologies of SB RAS, Novosibirsk, Russia
b BIOSOFT.RU Ltd, Novosibirsk, Russia
c Institute of Chemical Biology and Fundamental Medicine of SB RAS, Novosibirsk, Russia
References:
Abstract: Arterial hypertension is one of the most common diseases of the human cardiovascular system and is characterized by persistent increase in blood pressure. Normalization of blood pressure can be achieved by using antihypertensive drugs with various mechanisms of action. In this work, we investigated a modular mathematical model of the human cardiovascular system created earlier, and complemented it with pharmacodynamic models of five different classes of antihypertensive drugs with such exemplars as aliskiren, losartan, bisoprolol, enalapril and amlodipine. We used clinical trials found in the literature in order to validate the resulting model. Specifically, we generated a population of virtual patients with high blood pressure and modeled their treatment with these antihypertensive drugs. Eventually, the model predicted blood pressure decrease in good agreement with clinical trials. In this way, our model can be further used to optimize the choice of drugs for a particular patient.
Key words: population modeling, virtual patient, human cardiovascular system, arterial hypertension, antihypertensive drugs, computational modeling, BioUML.
Funding agency Grant number
Russian Foundation for Basic Research 16-01-00779
Received 15.01.2019, 17.05.2019, Published 24.05.2019
Document Type: Article
UDC: 51-76
Language: Russian
Citation: I. N. Kiselev, E. O. Kutumova, A. F. Kolpakova, G. I. Lifshits, F. A. Kolpakov, “Mathematical modeling of the antihypertensive drugs action”, Mat. Biolog. Bioinform., 14:1 (2019), 233–256
Citation in format AMSBIB
\Bibitem{KisKutKol19}
\by I.~N.~Kiselev, E.~O.~Kutumova, A.~F.~Kolpakova, G.~I.~Lifshits, F.~A.~Kolpakov
\paper Mathematical modeling of the antihypertensive drugs action
\jour Mat. Biolog. Bioinform.
\yr 2019
\vol 14
\issue 1
\pages 233--256
\mathnet{http://mi.mathnet.ru/mbb382}
\crossref{https://doi.org/10.17537/2019.14.233}
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