Аннотация:
New (E)-5-[2-(5-nitrofuran-2-yl)vinyl]-1,2,4-oxadiazoles and 5-(5-nitrofuran-2-yl)-1,2,4-oxadiazoles were synthesized via the base-promoted condensation of nitrofuran-containing acyl chlorides with amidoximes. Testing these compounds against Gram-negative E. coli, Gram-positive B. subtilis and S. aureus as well as M. tuberculosis HRv37 strain revealed three compounds being selectively antimycobacterial. None of these compounds displayed any cytotoxicity towards human pancreatic epithelioid carcinoma cell line, PANC-1.
Образец цитирования:
M. Yu. Krasavin, A. A. Shetnev, V. A. Panova, S. A. Ivanovskii, S. A. Kalinin, T. Vinogradova, V. V. Sharoyko, P. Yablonsky, “Hetaryl- and heteroarylvinyl-substituted nitrofurans identified as non-cytotoxic selective antitubercular agents”, Mendeleev Commun., 32:4 (2022), 452–453
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc692
https://www.mathnet.ru/rus/mendc/v32/i4/p452
Эта публикация цитируется в следующих 5 статьяx:
Marta Kučerová‐Chlupáčová, “Systematic Review on 1,2,3‐Oxadiazoles, 1,2,4‐Oxadiazoles, and 1,2,5‐Oxadiazoles in the Antimycobacterial Drug Discovery”, ChemMedChem, 2025
Lyubov Vinogradova, Alexey Lukin, Kristina Komarova, Maxim Zhuravlev, Artem Fadeev, Mikhail Chudinov, Elizaveta Rogacheva, Lyudmila Kraeva, Maxim Gureev, Yuri Porozov, Marine Dogonadze, Tatiana Vinogradova, “Molecular Periphery Design Allows Control of the New Nitrofurans Antimicrobial Selectivity”, Molecules, 29:14 (2024), 3364
K. A. Gomonov, V. V. Pelipko, I. A. Litvinov, S. I. Selivanov, R. I. Baichurin, S. V. Makarenko, “Nitrofuran-3-carboxylates: synthesis and structure”, Mendeleev Commun., 34:3 (2024), 398–400
A. Yu. Lukin, L. V. Vinogradova, K. Yu. Komarova, M. Yu. Krasavin, “Spirocyclic azetidines for drug discovery: Novel Boc-protected 7'H-spiro[azetidine-3,5'-furo[3,4-d ]pyrimidines]”, Mendeleev Commun., 33:3 (2023), 323–324
Alexander Sapegin, Elizaveta Rogacheva, Lyudmila Kraeva, Maxim Gureev, Marine Dogonadze, Tatiana Vinogradova, Petr Yablonsky, Saeed Balalaie, Sergey V. Baykov, Mikhail Krasavin, “Novel 5-Nitrofuran-Tagged Imidazo-Fused Azines and Azoles Amenable by the Groebke–Blackburn–Bienaymé Multicomponent Reaction: Activity Profile against ESKAPE Pathogens and Mycobacteria”, Biomedicines, 10:9 (2022), 2203
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