Аннотация:
An optimized synthesis of N-{5-[(1,11-dimethyl-4,8,12-trioxo-3,6,9-triazatricyclo[7.3.1.13,11]tetradec-6-yl)methyl]-indan-2-yl}-1,3-benzodioxole-5-carboxamide has been carried out from indan-2-one oxime in seven steps. In vitro studies using electrophysiological patch clamp technique have revealed a positive modulation effect of this compound on kainate induced currents in Purkinje neurons in a wide range of concentrations from 10–12 to 10–8 m.
Образец цитирования:
E. A. Golubeva, M. I. Lavrov, P. N. Veremeeva, E. M. Bovina, E. V. Radchenko, M. A. Topchiy, A. F. Asachenko, V. L. Zamoyski, V. V. Grigoriev, V. A. Palyulin, “New 1,11-dimethyl-3,6,9-triazatricyclo[7.3.1.13,11]tetradecane-4,8,12-trione derivative as an allosteric modulator of the glutamatergic system”, Mendeleev Commun., 33:1 (2023), 70–72
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc311
https://www.mathnet.ru/rus/mendc/v33/i1/p70
Эта публикация цитируется в следующих 6 статьяx:
James Matthews, Polina N. Veremeeva, Elena A. Golubeva, Mstislav I. Lavrov, Eugene V. Radchenko, Vladimir L. Zamoyski, Vladimir V. Grigoriev, Vladimir A. Palyulin, “Synthesis and modulatory activity of 3-acetyl-7-(benzofuran-5-carbonyl)-1,5-dimethyl-3,7-diazabicyclo[3.3.1]nonan-9-one on AMPA receptors”, Chem Heterocycl Comp, 2025
E. A. Golubeva, M. I. Lavrov, P. N. Veremeeva, J. Matthews, E. V. Radchenko, V. L. Zamoyski, V. V. Grigoriev, V. A. Palyulin, Mendeleev Commun., 35:2 (2025), 142–144
I. V. Svitanko, T. S. Pivina, “Molecular modeling in synthesis: from statistical methods to quantum chemistry and practical applications”, Russ Chem Bull, 73:5 (2024), 1093
J. Matthews, P. N. Veremeeva, E. A. Golubeva, M. I. Lavrov, E. V. Radchenko, M. A. Topchiy, V. L. Zamoyski, V. V. Grigoriev, V. A. Palyulin, “7-Benzyl-1,5-dimethyl-3-piperonyloyl-3,7-diazabicyclo[3.3.1]nonan-9-one as an allosteric modulator of glutamatergic system”, Mendeleev Commun., 34:3 (2024), 354–356
Elena A. Golubeva, Mstislav I. Lavrov, Polina N. Veremeeva, Tatiana V. Vyunova, Konstantin V. Shevchenko, Maxim A. Topchiy, Andrey F. Asachenko, Vladimir A. Palyulin, “New Allosteric Modulators of AMPA Receptors: Synthesis and Study of Their Functional Activity by Radioligand-Receptor Binding Analysis”, IJMS, 24:12 (2023), 10293
Elena A. Golubeva, Mstislav I. Lavrov, Eugene V. Radchenko, Vladimir A. Palyulin, “Diversity of AMPA Receptor Ligands: Chemotypes, Binding Modes, Mechanisms of Action, and Therapeutic Effects”, Biomolecules, 13:1 (2022), 56
Обратная связь: