One-pot multi-component synthesis and cytotoxic activity of terpenoid dimers containing azapolycyclic spacers

Novel terpenoid dimers linked through the E–E rings were synthesized by catalytic multicomponent condensation of amino derivatives of methyl maleopimarate with form-aldehyde and dimethyl-tetraazadecalin or tetraazaperhydro- tetracene. Primary screening of the synthesized terpenoid dimers for cytotoxic activity was performed.