Аннотация:
A facile synthetic approach to 5-arylamino-4-(5-nitrofuran- 2-yl)pyrimidines by the Buchwald–Hartwig cross-coupling with various anilines has been developed. All synthesized compounds demonstrated a significant level of in vitro antibacterial activity against Neisseria gonorrhoeae, Streptococcus pyogene and Staphylococcus aureus, including their drug-resistant strains, which is much higher than that of the commercial drug Spectinomycin.
Образец цитирования:
E. V. Verbitskiy, S. A. Baskakova, N. A. Gerasimova, N. P. Evstigneeva, N. V. Zil'berberg, N. V. Kungurov, M. A. Kravchenko, G. L. Rusinov, O. N. Chupakhin, V. N. Charushin, “New 5-arylamino-4-(5-nitrofuran-2-yl)pyrimidines as promising antibacterial agents”, Mendeleev Commun., 28:4 (2018), 393–395
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc1777
https://www.mathnet.ru/rus/mendc/v28/i4/p393
Эта публикация цитируется в следующих 13 статьяx:
Valery N. Charushin, Mikhail V. Varaksin, Egor V. Verbitskiy, Oleg N. Chupakhin, Advances in Heterocyclic Chemistry, 144, 2024, 1
A. Yu. Lukin, L. V. Vinogradova, K. Yu. Komarova, M. Yu. Krasavin, “Spirocyclic azetidines for drug discovery: Novel Boc-protected 7'H-spiro[azetidine-3,5'-furo[3,4-d ]pyrimidines]”, Mendeleev Commun., 33:3 (2023), 323–324
Matteo Mori, Andrea Tresoldi, Stefania Villa, Giulia Cazzaniga, Marco Bellinzoni, Fiorella Meneghetti, “5-(4-Nitrophenyl)furan-2-carboxylic Acid”, Molbank, 2022:4 (2022), M1515
Liu Yang, Wen Bo Xu, Liangpeng Sun, Changhao Zhang, Cheng Hua Jin, “SAR Analysis of Heterocyclic Compounds with Monocyclic and Bicyclic Structures as Antifungal Agents”, ChemMedChem, 17:12 (2022)
E. V. Verbitskiy, S. A. Baskakova, G. L. Rusinov, V. N. Charushin, “New approach to 5-arylamino-4-(5-aryloxyfuran-2-yl)pyrimidines: synthesis and antibacterial activity”, Russ Chem Bull, 70:5 (2021), 937
Majid M. Heravi, Vahideh Zadsirjan, Masoume Malmir, Leila Mohammadi, “Buchwald–Hartwig reaction: an update”, Monatsh Chem, 152:10 (2021), 1127
E. V. Verbitskiy, S. A. Baskakova, D. V. Belyaev, D. V. Vakhrusheva, N. I. Eremeeva, G. L. Rusinov, V. N. Charushin, “Renaissance of 4-(5-nitrofuran-2-yl)-5-arylamino substituted pyrimidines: microwave-assisted synthesis and antitubercular activity”, Mendeleev Commun., 31:2 (2021), 210–212
M. A. Prezent, S. V. Baranin, Yu. N. Bubnov, “A convenient synthesis of new (1,2,4-triazolylamino)pyrimidines from cyanamide precursor”, Mendeleev Commun., 30:4 (2020), 500–501
Asmaa Kamal Mourad, Fatehia K. Mohammed, Gamal Hassan Tammam, Shimaa Rabie Mohammed, “An Efficient Access to Pyrimidine‐based Polyfunctional Heterocycles with Anticipated Antibacterial Activity”, Journal of Heterocyclic Chem, 56:8 (2019), 2262
V. N. Charushin, O. N. Chupakhin, “Nucleophilic C—H functionalization of arenes: a contribution to green chemistry”, Russ Chem Bull, 68:3 (2019), 453
E. V. Verbitskiy, G. L. Rusinov, V. N. Charushin, O. N. Chupakhin, “Development of new antituberculosis drugs among of 1,3- and 1,4-diazines. Highlights and perspectives”, Russ Chem Bull, 68:12 (2019), 2172
N. A. Beliaev, T. V. Beryozkina, G. Lubec, V. A. Bakulev, “A catalyst-free one-step synthesis of N-pyrimidinyl amidines from endocyclic enamines and 4-azidopyrimidines”, Mendeleev Commun., 29:1 (2019), 50–52
K. N. Sedenkova, A. A. Nazarova, E. V. Khvatov, E. V. Dueva, A. A. Orlov, D. I. Osolodkin, Yu. K. Grishin, T. S. Kuznetsova, V. A. Palyulin, E. B. Averina, “A facile metal-free approach to N,N′-bis(1-oxidopyrimidin-4-yl)diamines with promising biological activity”, Mendeleev Commun., 28:6 (2018), 592–594
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