E. V. Nurieva, T. P. Trofimova, A. A. Alexeev, A. N. Proshin, E. A. Chesnakova, Yu. K. Grishin, K. A. Lyssenko, M. V. Filimonova, S. O. Bachurin, O. N. Zefirova, “Synthesis and antihypotensive properties of 2-amino-2-thiazoline analogues with enhanced lipophilicity”, Mendeleev Commun., 28:4 (2018), 390

Аннотация: In a search of nitric oxide synthase inhibitors with prolonged vasoconstrictive activity, a series of lipophilic cyclohexafused 2-amino-2-thiazolines was obtained via cyclization of tert-butyl- or benzoyl-substituted N-(cyclohex-2-en-1-yl)thioureas. The crystal structure of intermediate N-[(3aRS,7aSR)-3a,4,5,6,7,7a-hexahydro-1,3-benzothiazol-2-yl]benzamide hydrobromide was determined by X-ray analysis. One compound was found to cause pronounced and prolonged vasoconstrictive effect after single injection to the Wystar rats with lipopolysaccharide induced acute endotoxic (vasodilatation) shock.

Эта публикация цитируется в следующих 11 статьяx:

N. A. Zefirov, E. V. Nurieva, I. A. Elisseev, Sh. A. Khasanov, M. A. Niukalova, V. V. Zarubaev, O. N. Zefirova, Mendeleev Commun., 35:1 (2025), 50–53
Olga A. Gromova, Marina V. Filimonova, Ivan Yu. Torshin, Daria Е. Frolova, “Study of antitumor effects of human placenta hydrolysate on PC-3, OAW-42, BT-474 cell cultures”, Terapevticheskii arkhiv, 96:3 (2024), 266
E. V. Nurieva, A. A. Alexeev, N. A. Zefirov, E. R. Milaeva, N. V. Kovaleva, A. N. Proshin, G. F. Makhaeva, O. N. Zefirova, “Annulated bicyclic isothioureas: identification of active and selective butyrylcholinesterase inhibitors”, Mendeleev Commun., 33:1 (2023), 77–79
Marina Filimonova, Ljudmila Shevchenko, Victoria Makarchuk, Alina Saburova, Petr Shegay, Andrey Kaprin, Sergey Ivanov, Alexander Filimonov, “Preclinical studies of NOS inhibitor T1059 vasopressor activity on the models of acute hemorrhagic shock in rats and dogs”, Front. Pharmacol., 13 (2022)
A. A. Alexeev, E. V. Nurieva, I. A. Elisseev, E. R. Milaeva, K. A. Lyssenko, O. N. Zefirova, “Bicyclic isothioureas for conjugation with tubulin targeted anticancer agents”, Mendeleev Commun., 32:6 (2022), 766–768
Anna V. Evdokimova, Alexander A. Alexeev, Evgeniya V. Nurieva, Elena R. Milaeva, Sergei A. Kuznetsov, Olga N. Zefirova, “N-(4-Methoxyphenyl)-substituted bicyclic isothioureas: effect on morphology of cancer cells”, Mendeleev Communications, 31:3 (2021), 288
Joel I. Badillo-Gómez, Maryse Gouygou, M. Carmen Ortega-Alfaro, José G. López-Cortés, “2-Thiazolines: an update on synthetic methods and catalysis”, Org. Biomol. Chem., 19:35 (2021), 7497
Evgeniya V. Nurieva, Alexander A. Alexeev, Olga N. Zefirova, “Cyclic Isothiourea in Drug Design”, Chem Heterocycl Comp, 57:9 (2021), 889
E. V. Nurieva, A. A. Alexeev, Yu. K. Grishin, V. A. Tafeenko, O. N. Zefirova, “New compounds with 4-azatricyclo[4.3.1.13,8]undecane framework”, Mendeleev Commun., 30:2 (2020), 145–146
Alexander A. Alexeev, Evgeniya V. Nurieva, Konstantin A. Lyssenko, Yuri K. Grishin, Olga N. Zefirova, “Novel structural type of bridged urea derivatives bearing azatricyclo[4.3.1.03,8]decane moiety”, Struct Chem, 30:2 (2019), 473
A. A. Alexeev, E. V. Nurieva, T. P. Trofimova, E. A. Chesnakova, Yu. K. Grishin, K. A. Lyssenko, M. V. Filimonova, O. N. Zefirova, “Bicyclic bridged isothioureas: synthesis and evaluation of activity in a model of lipopolysaccharide-induced septic shock”, Mendeleev Commun., 29:1 (2019), 14–16