Аннотация:
A series of combretastatin analogues, diarylpyrazoles and diarylisoxazoles, have been synthesized and evaluated for their antimitotic tubulin-binding activity using the phenotypic sea urchin (Paracentrotus lividus) embryo assay. One pyrazole analogue and four isoxazole analogues have been identified as potent antimitotic agents comparable with combretastatins A-2 and A-4, with the lowest observable effective concentration of 1–10nmoldm−3 for cleavage alteration of the test embryos.
Образец цитирования:
D. V. Tsyganov, M. N. Semenova, L. D. Konyushkin, V. I. Ushkarov, M. M. Raihstat, V. V. Semenov, “A convenient synthesis of cis-restricted combretastatin analogues with pyrazole and isoxazole cores”, Mendeleev Commun., 29:2 (2019), 163–165
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc1457
https://www.mathnet.ru/rus/mendc/v29/i2/p163
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