A. A. Alexeev, E. V. Nurieva, T. P. Trofimova, E. A. Chesnakova, Yu. K. Grishin, K. A. Lyssenko, M. V. Filimonova, O. N. Zefirova, “Bicyclic bridged isothioureas: synthesis and evaluation of activity in a model of lipopolysaccharide-induced septic shock”, Mendeleev Commun., 29:1 (2019), 14

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Mendeleev Communications

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Mendeleev Communications, 2019, том 29, выпуск 1, страницы 14–16
DOI: https://doi.org/10.1016/j.mencom.2019.01.003 (Mi mendc1405)

Эта публикация цитируется в 10 научных статьях (всего в 10 статьях)

Communications

Bicyclic bridged isothioureas: synthesis and evaluation of activity in a model of lipopolysaccharide-induced septic shock

A. A. Alexeev^a, E. V. Nurieva^a, T. P. Trofimova^ab, E. A. Chesnakova^c, Yu. K. Grishin^a, K. A. Lyssenko^ad, M. V. Filimonova^c, O. N. Zefirova^ab

^a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation
^c Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk, Kaluga Region, Russian Federation
^d A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russian Federation

PDF полного текста (368 kB) Список цитирования (10)

DOI: https://doi.org/10.1016/j.mencom.2019.01.003

Graphic abstract: Bicyclic bridged isothioureas: synthesis and evaluation of activity in a model of lipopolysaccharide-induced septic shock

Аннотация: A convenient synthetic pathway to bridged isothioureas via cyclization of tert-butyl-substituted cyclohex-3-en-1-ylthiourea by the action of bromine has been developed. The effective use of tert-butyl protective group was demonstrated, and the crystal structure of synthesized (3aRS,7SR,7aRS)-7-bromo-3a,4, 5,6,7,7a-hexahydro-1,3-benzothiazol-2-amine hydrobromide was determined by X-ray analysis. (1RS,5SR)-2-Thia-4-aza-bicyclo[3.3.1]non-3-en-3-amine as a strong inducible nitric oxide synthase inhibitor in vitro surprisingly caused additional hypotension in LPS-induced acute endotoxic shock model while its C⁸-hydroxy-derivative displayed prominent and durable vasoconstrictive effect.

Тип публикации: Статья

Язык публикации: английский

*Дополнительные материалы:*
		Supplementary_data_1.pdf	(708.5 Kb)

Образец цитирования: A. A. Alexeev, E. V. Nurieva, T. P. Trofimova, E. A. Chesnakova, Yu. K. Grishin, K. A. Lyssenko, M. V. Filimonova, O. N. Zefirova, “Bicyclic bridged isothioureas: synthesis and evaluation of activity in a model of lipopolysaccharide-induced septic shock”, Mendeleev Commun., 29:1 (2019), 14–16

Образцы ссылок на эту страницу:

https://www.mathnet.ru/rus/mendc1405

https://www.mathnet.ru/rus/mendc/v29/i1/p14

Эта публикация цитируется в следующих 10 статьяx:

N. A. Zefirov, E. V. Nurieva, I. A. Elisseev, Sh. A. Khasanov, M. A. Niukalova, V. V. Zarubaev, O. N. Zefirova, Mendeleev Commun., 35:1 (2025), 50–53
E. V. Nurieva, A. A. Alexeev, N. A. Zefirov, E. R. Milaeva, N. V. Kovaleva, A. N. Proshin, G. F. Makhaeva, O. N. Zefirova, “Annulated bicyclic isothioureas: identification of active and selective butyrylcholinesterase inhibitors”, Mendeleev Commun., 33:1 (2023), 77–79
Barbara Parrino, Stella Cascioferro, Daniela Carbone, Camilla Pecoraro, Girolamo Cirrincione, Patrizia Diana, Advances in Heterocyclic Chemistry, 136, 2022, 1
Barbara Parrino, Stella Cascioferro, Daniela Carbone, Girolamo Cirrincione, Patrizia Diana, Comprehensive Heterocyclic Chemistry IV, 2022, 150
Marina Filimonova, Ljudmila Shevchenko, Victoria Makarchuk, Alina Saburova, Petr Shegay, Andrey Kaprin, Sergey Ivanov, Alexander Filimonov, “Preclinical studies of NOS inhibitor T1059 vasopressor activity on the models of acute hemorrhagic shock in rats and dogs”, Front. Pharmacol., 13 (2022)
Irina V. Galkina, Dmitriy I. Bakhtiyarov, Luiza M. Usupova, Alexander V. Gerasimov, Marina P. Shulaeva, Oskar K. Pozdeev, Ahat V. Ilyasov, Daut R. Islamov, Konstantin S. Usachev, Yulia V. Bakhtiyarova, Vladimir I. Galkin, “Antimicrobial activity of novel isothiuronium salts with 7-chloro-4,6-dinitrobenzofuroxan-5-olate anion”, Mendeleev Communications, 31:3 (2021), 365
Anna V. Evdokimova, Alexander A. Alexeev, Evgeniya V. Nurieva, Elena R. Milaeva, Sergei A. Kuznetsov, Olga N. Zefirova, “N-(4-Methoxyphenyl)-substituted bicyclic isothioureas: effect on morphology of cancer cells”, Mendeleev Communications, 31:3 (2021), 288
Evgeniya V. Nurieva, Alexander A. Alexeev, Olga N. Zefirova, “Cyclic Isothiourea in Drug Design”, Chem Heterocycl Comp, 57:9 (2021), 889
V. V. Baranov, T. N. Vol'khina, Yu. V. Nelyubina, A. N. Kravchenko, “New aspects of reactions of methyl (thio)ureas with benzil”, Mendeleev Commun., 31:5 (2021), 673–676
E. V. Nurieva, A. A. Alexeev, Yu. K. Grishin, V. A. Tafeenko, O. N. Zefirova, “New compounds with 4-azatricyclo[4.3.1.13,8]undecane framework”, Mendeleev Commun., 30:2 (2020), 145–146

Citing articles in Google Scholar: Russian citations, English citations
Related articles in Google Scholar: Russian articles, English articles

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