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Эта публикация цитируется в 9 научных статьях (всего в 9 статьях)
Bicyclic bridged isothioureas: synthesis and evaluation of activity in a model of lipopolysaccharide-induced septic shock
A. A. Alexeeva, E. V. Nurievaa, T. P. Trofimovaab, E. A. Chesnakovac, Yu. K. Grishina, K. A. Lyssenkoad, M. V. Filimonovac, O. N. Zefirovaab
a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
b Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation
c Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk, Kaluga Region, Russian Federation
d A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russian Federation
Аннотация:
A convenient synthetic pathway to bridged isothioureas via cyclization of tert-butyl-substituted cyclohex-3-en-1-ylthiourea by the action of bromine has been developed. The effective use of tert-butyl protective group was demonstrated, and the crystal structure of synthesized (3aRS,7SR,7aRS)-7-bromo-3a,4,5,6,7,7a-hexahydro-1,3-benzothiazol-2-amine hydrobromide was determined by X-ray analysis. (1RS,5SR)-2-Thia-4-azabicyclo[3.3.1]non-3-en-3-amine as a strong inducible nitric oxide synthase inhibitor in vitro surprisingly caused additional hypotension in LPS-induced acute endotoxic shock model while its C8-hydroxy-derivative displayed prominent and durable vasoconstrictive effect.
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https://www.mathnet.ru/rus/mendc1405
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