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Эта публикация цитируется в 7 научных статьях (всего в 7 статьях)
Synthesis and biological activity of polyfluorinated p-aminosalicylic acids and their amides
Ya. V. Burgartab, I. V. Shchura, E. V. Shchegolkovab, V. I. Saloutinab
a I.Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation
b Institute of Chemical Engineering, Ural Federal University, Ekaterinburg, Russian Federation
Аннотация:
Polyfluorinated analogues of salicylamide and p-aminosalicylic acid have been synthesized based on methyl polyfluorosalicylates. Polyfluorosalicylamides were obtained by the reaction with aqueous ammonia, while 4-aminopolyfluorosalicylic
acids were prepared in two steps via regio-oriented nucleophilic replacement of para-positioned fluorine atom with azido group followed by its reduction. 3,4,5-Trifluorosalicylamide showed pronounced analgesic in vivo activity in hot plate test while 4-amino-3,5-difluorosalicylic acid revealed high tuberculostatic activity.
Ключевые слова:
salicylamide, p-aminosalicylic acid, polyfluoroarenes, organofluorine compounds, aromatic nucleophilic substitution,
tuberculostatic activity, analgesic activity, acute toxicity.
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc1277
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