Аннотация:
Polyfluorinated analogues of salicylamide and p-aminosalicylic acid have been synthesized based on methyl polyfluorosalicylates. Polyfluorosalicylamides were obtained by the reaction with aqueous ammonia, while 4-aminopolyfluorosalicylic acids were prepared in two steps via regio-oriented nucleophilic replacement of para-positioned fluorine atom with azido group followed by its reduction. 3,4,5-Trifluorosalicylamide showed pronounced analgesic in vivo activity in hot plate test while 4-amino-3,5-difluorosalicylic acid revealed high tuberculostatic activity.
Образец цитирования:
Ya. V. Burgart, I. V. Shchur, E. V. Shchegolkov, V. I. Saloutin, “Synthesis and biological activity of polyfluorinated p-aminosalicylic acids and their amides”, Mendeleev Commun., 30:5 (2020), 636–638
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc1277
https://www.mathnet.ru/rus/mendc/v30/i5/p636
Эта публикация цитируется в следующих 7 статьяx:
A. D. Baranovskiy, E. V. Shchegolkov, Ya. V. Burgart, O. P. Krasnykh, K. O. Malysheva, N. A. Gerasimova, N. P. Evstigneeva, V. I. Saloutin, “Synthesis of 4-(N-cycloalkylamino)-substituted polyfluorobenzoic acids and their esters”, Russ Chem Bull, 73:7 (2024), 1984
Paola Borrego-Muñoz, Ericsson Coy-Barrera, Diego Quiroga, “New Strategies in the Chemical Control of Fusarium oxysporum Using
Synthetic Bioisosteres of Secondary Metabolites: A Review of the Synthetic
Methods for Novel Compounds with Potential Antifungal Activity”, MROC, 21:8 (2024), 794
Ga Ram Lee, Rama Moorthy Appa, Sung Chul Hong, “Modification of polyolefins utilizing C–H insertion of azides: Azidoformate end-functionalized polystyrene for modifying polypropylene”, Polymer Testing, 141 (2024), 108635
Е. В. Щегольков, Я. В. Бургарт, И. В. Щур, В. И. Салоутин, “Полифторсодержащие бензойные кислоты как перспективные реагенты для органического синтеза
и медицинской химии”, Усп. хим., 93:8 (2024), RCR5131 ; E. V. Shchegolkov, Ya. V. Burgart, I. V. Shchur, V. I. Saloutin, “Polyfluorinated benzoic acids as promising reagents for organic synthesis and medicinal chemistry”, Russian Chem. Reviews, 93:8 (2024), RCR5131
Yanina Burgart, Evgeny Shchegolkov, Irina Shchur, Dmitry Kopchuk, Natalia Gerasimova, Sophia Borisevich, Natalia Evstigneeva, Grigory Zyryanov, Maria Savchuk, Maria Ulitko, Natalia Zilberberg, Nikolai Kungurov, Victor Saloutin, Valery Charushin, Oleg Chupakhin, “Promising Antifungal and Antibacterial Agents Based on 5‐Aryl‐2,2′‐bipyridines and Their Heteroligand Salicylate Metal Complexes: Synthesis, Bioevaluation, Molecular Docking”, ChemMedChem, 17:3 (2022)
Irina V. Shchur, Evgeny V. Shchegolkov, Yanina V. Burgart, Victor I. Saloutin, ACTUAL PROBLEMS OF ORGANIC CHEMISTRY AND BIOTECHNOLOGY (OCBT2020): Proceedings of the International Scientific Conference, 2390, ACTUAL PROBLEMS OF ORGANIC CHEMISTRY AND BIOTECHNOLOGY (OCBT2020): Proceedings of the International Scientific Conference, 2022, 020078
Yiying Du, Qiugui Zeng, Ling Yuan, Lirong He, “Post-polymerization modification based on reactive fluorinated polymers reaction”, Journal of Macromolecular Science, Part A, 58:8 (2021), 521
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