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Эта публикация цитируется в 2 научных статьях (всего в 2 статьях)
Functionalization of 1,2-diphenylpyrazolidine-3,5-dione with polyfluoroalkyl-containing 2- and 3-oxo esters
O. G. Khudina, Ya. V. Burgart, V. I. Saloutin
I.Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation
Аннотация:
Fluorine-containing analogues of non-steroidal antiinflammatory drugs Tribuzone and Ketazone have been synthesized by reaction of 1,2-diphenylpyrazolidine-3,5-
dione with polyfluoroalkyl-containing 3- and 2-oxo esters. Ethyl 3-(pyrazolidin-4-yl)-3-(polyfluoroalkyl)prop-2-enoates have been obtained as Knoevenagel reaction products from 3-oxo esters in the presence of l-proline. Unlike with 3-oxo esters, addition of ethyl 3,3,3-trifluoro-2-oxopropanoate
under basic conditions afforded ethyl 2-(pyrazolidin-4-yl)-3,3,3-trifluoro-2-hydroxypropanoate or its salt without elimination of a water molecule.
Ключевые слова:
Knoevenagel reaction, 1,2-diphenylpyrazolidine-3,5-dione, polyfluoroalkyl 3-oxo esters, polyfluoroalkyl 2-oxo esters,
non-steroidal anti-inflammatory drugs.
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc1275
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