Аннотация:
Four anhydrides of 1-(carboxymethyl)pyrrole-2-carboxylic acids bearing electron-withdrawing substituents at positions 6 or 7 of the bicyclic system have been investigated in the Castagnoli–Cushman reaction with imines. 6-Benzoyl- and 7-sulfamoyl-substituted anhydrides demonstrated lower reactivity while 7-benzoyl derivative displayed broader substrate scope. These findings have been rationalized from the mechanistic perspective.
Образец цитирования:
M. E. Chizhova, D. V. Dar'in, M. Yu. Krasavin, “The Castagnoli–Cushman reaction of bicyclic pyrrole dicarboxylic anhydrides bearing electron-withdrawing substituents”, Mendeleev Commun., 30:4 (2020), 496–497
José Luis Ramiro, Sonia Martínez-Caballero, Ana G. Neo, Jesús Díaz, Carlos F. Marcos, “The Castagnoli–Cushman Reaction”, Molecules, 28:6 (2023), 2654
Pieterjan Winant, Tomas Horsten, Shaiani Gil de Melo, Flavio Emery, Wim Dehaen, “A Review of the Synthetic Strategies toward Dihydropyrrolo[1,2-a]Pyrazinones”, Organics, 2:2 (2021), 118
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