Russian Chemical Reviews
RUS  ENG    JOURNALS   PEOPLE   ORGANISATIONS   CONFERENCES   SEMINARS   VIDEO LIBRARY   PACKAGE AMSBIB  
General information
Latest issue
Archive
Impact factor
Guidelines for authors

Search papers
Search references

RSS
Latest issue
Current issues
Archive issues
What is RSS


Usp. Khim.:
Year:
Volume:
Issue:
Page:
Find




Personal entry:
Login:
Password:
Save password
Enter
Forgotten password?
Register

Russian Chemical Reviews, 2016, Volume 85, Issue 8, Pages 854–879
DOI: https://doi.org/10.1070/RCR4614 (Mi rcr4123) 		 
This article is cited in 23 scientific papers (total in 23 papers)

Computer-aided prediction of xenobiotic metabolism in humans

V. M. Bezhentseva, O. A. Tarasovaa, A. V. Dmitrieva, A. V. Rudika, A. A. Laguninba, D. A. Filimonova, V. V. Poroikova

a Institute of Biomedical Chemistry, Moscow
b Russian National Research Medical University named after N. I. Pirogov
English full-text Citations (23)
DOI: https://doi.org/10.1070/RCR4614
Abstract: The review describes the main databases containing information about the metabolism of xenobiotics, including data on drug metabolism, metabolic enzymes, schemes of biotransformation and the structures of some substrates and metabolites. Computational approaches used to predict the interaction of xenobiotics with metabolic enzymes, to identify the sites of metabolism in the molecule and to generate structures of potential metabolites for subsequent evaluation of their properties are considered. The advantages and limitations of particular computational methods for metabolism prediction are indicated and the prospects for their applications to improve the safety and efficacy of new drugs are discussed.
The bibliography includes 165 references.
Received: 19.11.2015
Russian version:
Uspekhi Khimii, 2016, Volume 85, Issue 8, Pages 854–879
DOI: https://doi.org/10.1070/RCR4614
Bibliographic databases:
Document Type: Article
Language: English
Original paper language: Russian
Citation: V. M. Bezhentsev, O. A. Tarasova, A. V. Dmitriev, A. V. Rudik, A. A. Lagunin, D. A. Filimonov, V. V. Poroikov, “Computer-aided prediction of xenobiotic metabolism in humans”, Usp. Khim., 85:8 (2016), 854–879; Russian Chem. Reviews, 85:8 (2016), 854–879
Citation in format AMSBIB
\Bibitem{BezTarDmi16}
\by V.~M.~Bezhentsev, O.~A.~Tarasova, A.~V.~Dmitriev, A.~V.~Rudik, A.~A.~Lagunin, D.~A.~Filimonov, V.~V.~Poroikov
\paper Computer-aided prediction of xenobiotic metabolism in humans
\jour Usp. Khim.
\yr 2016
\vol 85
\issue 8
\pages 854--879
\mathnet{http://mi.mathnet.ru/rcr4123}
\crossref{https://doi.org/10.1070/RCR4614}
\adsnasa{https://adsabs.harvard.edu/cgi-bin/bib_query?2016RuCRv..85..854B}
\elib{https://elibrary.ru/item.asp?id=26337845}
\transl
\jour Russian Chem. Reviews
\yr 2016
\vol 85
\issue 8
\pages 854--879
\crossref{https://doi.org/10.1070/RCR4614}
\isi{https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Publons&SrcAuth=Publons_CEL&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=000382300600004}
\scopus{https://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-84987760527}
Linking options:
  • https://www.mathnet.ru/eng/rcr4123
  • https://doi.org/10.1070/RCR4614
  • https://www.mathnet.ru/eng/rcr/v85/i8/p854
    • This publication is cited in the following 23 articles:
    Citing articles in Google Scholar: Russian citations, English citations
    Related articles in Google Scholar: Russian articles, English articles
    		Успехи химии Russian Chemical Reviews
    Statistics & downloads:
    Abstract page:140
     
      Contact us:
    		  Terms of Use  Registration to the website  Logotypes © Steklov Mathematical Institute RAS, 2024