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Optics and Spectroscopy, 2020, Volume 128, Issue 6, Pages 846–851
DOI: https://doi.org/10.21883/OS.2020.06.49419.34-20 (Mi os408) 		 
This article is cited in 3 scientific papers (total in 3 papers)

Saratov Fall Meeting 19: 7th International Symposium ''Optics and Biophotonics'', 23d International School for Junior Scientists and Students on Optics, Laser Physics & Biophotonics and 4th School on Advanced Fluorescence Imaging Methods
Biophotonics

Efficiency of plasmonic photothermal therapy of experimental tumors

A. B. Bucharskayaa, G. N. Maslyakovaa, M. L. Chekhonatskayaa, N. B. Zakharovaa, G. S. Terentyuka, N. A. Navolokina, B. N. Khlebtsovb, N. G. Khlebtsovb, V. D. Genincd, A. N. Bashkatovcd, È. A. Geninacd, V. V. Tuchincde

a Saratov State Medical University named after V. I. Razumovsky
b Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences, Saratov
c Saratov State University
d Tomsk State University
e Institute of Precision Mechanics and Control, Russian Academy of Sciences, Saratov
Full-text PDF (2666 kB) Citations (3)
DOI: https://doi.org/10.21883/OS.2020.06.49419.34-20
Abstract: The purpose of this study was to investigate the prognostic factors of plasmonic photothermal therapy (PPT) efficiency in rats with transplanted liver cancer on the basis of assessment of the degree of tumor vascularization. Before any exposure, rats with transplanted liver cancer PC-1 were subjected to Doppler ultrasonography to assess the degree of vascularization of transplanted tumors. Half of the animals with the transplanted tumors were withdrawn from the experiment after Doppler ultrasonography to determine the content of vascular factors in blood serum by enzyme immunoassay and in tumor tissue by immunohistochemical method. After three intravenous injections of polyethylene glycol-coated gold nanorods (GNRs) at a dose of 0.4 mq/mL, the transplanted tumors were irradiated percutaneously with infrared laser radiation at a wavelength of 808 nm, followed by thermography of local tumor heating. The animals were withdrawn from the experiment 24 h later, and tumor tissue samples were taken for histological examination. It is found that the accumulation of gold in the tumor tissue and the PPT efficiency at repeated intravenous GNR injections are determined by the presence of formed vasculature in the tumor.
Keywords: gold nanorods, infrared laser radiation, intravenous injection, Doppler ultrasonography, vascular endothelial growth factor, morphology.
Funding agency Grant number
Ministry of Science and Higher Education of the Russian Federation 0203042330329
Russian Foundation for Basic Research 18-52-7803 Итал-т
19-32-90224
Russian Academy of Sciences - Federal Agency for Scientific Organizations 32
Work performed under the state assignment of the Ministry of Health of the Russian Federation “Molecular Markers and Gold Nanoparticles: Application in Theranostics in Experimental and Clinical Oncology” (state registration no. 0203042330329) and the Russian Foundation for Basic Research (project no. 18-52-7803 (Ital-t)).
Received: 11.12.2019
Revised: 01.02.2020
Accepted: 28.02.2020
English version:
Optics and Spectroscopy, 2020, Volume 128, Issue 6, Pages 849–854
DOI: https://doi.org/10.1134/S0030400X2006003X
Bibliographic databases:
Document Type: Article
Language: Russian
Citation: A. B. Bucharskaya, G. N. Maslyakova, M. L. Chekhonatskaya, N. B. Zakharova, G. S. Terentyuk, N. A. Navolokin, B. N. Khlebtsov, N. G. Khlebtsov, V. D. Genin, A. N. Bashkatov, È. A. Genina, V. V. Tuchin, “Efficiency of plasmonic photothermal therapy of experimental tumors”, Optics and Spectroscopy, 128:6 (2020), 846–851; Optics and Spectroscopy, 128:6 (2020), 849–854
Citation in format AMSBIB
\Bibitem{BucMasChe20}
\by A.~B.~Bucharskaya, G.~N.~Maslyakova, M.~L.~Chekhonatskaya, N.~B.~Zakharova, G.~S.~Terentyuk, N.~A.~Navolokin, B.~N.~Khlebtsov, N.~G.~Khlebtsov, V.~D.~Genin, A.~N.~Bashkatov, \`E.~A.~Genina, V.~V.~Tuchin
\paper Efficiency of plasmonic photothermal therapy of experimental tumors
\jour Optics and Spectroscopy
\yr 2020
\vol 128
\issue 6
\pages 846--851
\mathnet{http://mi.mathnet.ru/os408}
\crossref{https://doi.org/10.21883/OS.2020.06.49419.34-20}
\elib{https://elibrary.ru/item.asp?id=43808070}
\transl
\jour Optics and Spectroscopy
\yr 2020
\vol 128
\issue 6
\pages 849--854
\crossref{https://doi.org/10.1134/S0030400X2006003X}
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