K. S. Egorova, A. V. Posvyatenko, A. S. Galushko, A. E. Kolesnikov, “Assessing the contribution of reaction components to the overall toxicity of synthesis of 4-methoxy-4'-nitro-1,1'-biphenyl”, Mendeleev Commun., 34:2 (2024), 181

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Mendeleev Communications, 2024, Volume 34, Issue 2, Pages 181–184
DOI: https://doi.org/10.1016/j.mencom.2024.02.007 (Mi mendc76)

Communications

Assessing the contribution of reaction components to the overall toxicity of synthesis of 4-methoxy-4'-nitro-1,1'-biphenyl

K. S. Egorova^a, A. V. Posvyatenko^ab, A. S. Galushko^a, A. E. Kolesnikov^a

^a N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^b Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russian Federation

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DOI: https://doi.org/10.1016/j.mencom.2024.02.007

Graphic abstract: Assessing the contribution of reaction components to the overall toxicity of synthesis of 4-methoxy-4<i>'</i>-nitro-1,1<i>'</i>-biphenyl

Abstract: Using bio-Strips and cytotoxicity potentials, the least and most harmful substances involved in the synthesis of 4-methoxy-4'-nitro-1,1'-biphenyl from 4-methoxyphenyl- boronic acid and aryl halide were identified. A total of 36 synthetic routes were analyzed.

Keywords: C–C cross-coupling, 4-methoxy-4'-nitro-1,1'-biphenyl, toxicity, cytotoxicity, bio-Profile, bio-Strip, cytotoxicity potential.

Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(2.3 Mb)

Citation: K. S. Egorova, A. V. Posvyatenko, A. S. Galushko, A. E. Kolesnikov, “Assessing the contribution of reaction components to the overall toxicity of synthesis of 4-methoxy-4'-nitro-1,1'-biphenyl”, Mendeleev Commun., 34:2 (2024), 181–184

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Citing articles in Google Scholar: Russian citations, English citations
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