O. A. Kraevaya, E. A. Khakina, N. A. Emelianov, A. F. Shestakov, T. E. Sashenkova, D. V. Mishchenko, P. A. Troshin, “Integration of anticancer drug ruboxyl into the membrane of fullerene-based vesicle enhances its therapeutic performance”, Mendeleev Commun., 34:2 (2024), 178

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Mendeleev Communications, 2024, Volume 34, Issue 2, Pages 178–180
DOI: https://doi.org/10.1016/j.mencom.2024.02.006 (Mi mendc75)

This article is cited in 2 scientific papers (total in 2 papers)

Communications

Integration of anticancer drug ruboxyl into the membrane of fullerene-based vesicle enhances its therapeutic performance

O. A. Kraevaya^a, E. A. Khakina^b, N. A. Emelianov^a, A. F. Shestakov^ac, T. E. Sashenkova^a, D. V. Mishchenko^acd, P. A. Troshin^ae

^a Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation
^b A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russian Federation
^c Department of Fundamental Physical and Chemical Engineering, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^d Moscow Region State Pedagogical University, Mytishi, Moscow Region, Russian Federation
^e Zhengzhou Research Institute, Harbin Institute of Technology, Zhengzhou, China

Full-text PDF (702 kB) Citations (2)

DOI: https://doi.org/10.1016/j.mencom.2024.02.006

Graphic abstract: Integration of anticancer drug ruboxyl into the membrane of fullerene-based vesicle enhances its therapeutic performance

Abstract: The supramolecular complexation of anthracycline antibiotic ruboxyl with water-soluble fullerene derivative was visualized by scattering scanning near-field optical microscopy, and the effects of this complexation on the antileukemic activity in vivo were evaluated. Treatment of mice with P388 lymphocytic leukemia with ruboxyl resulted in 13% of cured animals, while similar treatment with ruboxyl–fullerene derivative combination caused 63% curing.

Keywords: water-soluble fullerene derivative, ruboxyl, leukemia, vesicles, IR s-SNOM.

Document Type: Article

Language: English

*Supplementary materials:*
		Supplementary_data_1.pdf	(748.4 Kb)

Citation: O. A. Kraevaya, E. A. Khakina, N. A. Emelianov, A. F. Shestakov, T. E. Sashenkova, D. V. Mishchenko, P. A. Troshin, “Integration of anticancer drug ruboxyl into the membrane of fullerene-based vesicle enhances its therapeutic performance”, Mendeleev Commun., 34:2 (2024), 178–180

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https://www.mathnet.ru/eng/mendc/v34/i2/p178

This publication is cited in the following 2 articles:

Olga Bolshakova, Olga Zherebyatieva, Svetlana V. Sarantseva, “Fullerenes in vivo. Toxicity and protective effects”, Nanotoxicology, 2025, 1
D. A. Poletaeva, A. V. Smolina, V. N. Varfolomeev, N. N. Lashmanov, E. N. Klimanova, E. A. Khakina, O. A. Kraevaya, P. A. Troshin, I. I. Faingold, “Influence of Fullerene–Ruboxyl Dyad on Markers of Mitochondrial Dysfunction In Vitro”, Nanotechnol Russia, 19:3 (2024), 461

Citing articles in Google Scholar: Russian citations, English citations
Related articles in Google Scholar: Russian articles, English articles

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