Abstract:
A newly described enzymatically formed ω-hydroxy metabolite of hepoxilin A3 (HxA3) has been prepared via total synthesis involving polyacetylenic intermediates and Mitsunobu rearrangement of the intermediate putative ω-hydroxy metabolite of hepoxilin B3.
Document Type:
Article
Language: English
Citation:
P. M. Demin, T. A. Manukina, C. R. Pace-Asciak, K. K. Pivnitsky, “Total synthesis of 20-hydroxy-hepoxilins, new metabolites of the hepoxilin family”, Mendeleev Commun., 6:4 (1996), 130–132
Linking options:
https://www.mathnet.ru/eng/mendc4946
https://www.mathnet.ru/eng/mendc/v6/i4/p130
This publication is cited in the following 7 articles:
Cecil R. Pace-Asciak, “Hepoxilins in cancer and inflammation—use of hepoxilin antagonists”, Cancer Metastasis Rev, 30:3-4 (2011), 493
K. C. Kumara Swamy, N. N. Bhuvan Kumar, E. Balaraman, K. V. P. Pavan Kumar, “Mitsunobu and Related Reactions: Advances and Applications”, Chem. Rev., 109:6 (2009), 2551
Cecil R. Pace-Asciak, Denis Reynaud, Olga Rounova, Peter Demin, Kazimir K. Pivnitsky, Advances in Experimental Medicine and Biology, 469, Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4, 1999, 535
M. A. Lapitskaya, G. V. Zatonsky, K. K. Pivnitsky, “Enantiomeric NMR analysis of organic acids with the Corey chiral controller”, Mendeleev Commun., 9:4 (1999), 149–151
Denis Reynaud, Olga Rounova, Peter M Demin, Kazimir K Pivnitsky, Cecil R Pace-Asciak, “Hepoxilin A3 is oxidized by human neutrophils into its ω-hydroxy metabolite by an activity independent of LTB4 ω-hydroxylase”, Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1348:3 (1997), 287
P. M. Demin, D. M. Kochev, H. Perrier, C. R. Pace-Asciak, K. K. Pivnitsky, “Synthesis of a photoaffinic hepoxilin analog”, Mendeleev Commun., 7:3 (1997), 90–91
P. M. DEMIN, T. A. MANUKINA, C. R. PACE‐ASCIAK, K. K. PIVNITSKY, “ChemInform Abstract: Total Synthesis of 20‐Hydroxy‐hepoxilins, New Metabolites of the Hepoxilin Family.”, ChemInform, 27:46 (1996)
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