This article is cited in 1 scientific paper (total in 1 paper)
Communications
Novel sulfonamide-functionalized arylidene indolones as potent α-glucosidase inhibitors: Synthesis, characterization, and in vitro and in silico studies
aHanoi University of Pharmacy, Phan Chu Trinh, Hoan Kiem, Hanoi, Vietnam bNguyen Gia Thieu High School, Long Bien, Gia Lam, Hanoi, Vietnam cFaculty of Chemistry, University of Science, Vietnam National University, Hanoi, Hoan Kiem, Hanoi, Vietnam
Abstract:
3-Arylidene-1-(2,6-dichlorophenyl)indolones and in particular their 5-methylaminosulfonyl derivatives efficiently inhibit α-glucosidase enzyme. The results are corroborated by in silico docking studies which show the binding of aminosulfonyl derivatives to be more favorable due to additional hydrogen bonding. The most active compound of the series shows the IC50 of 6.19 μm.
Citation:
G. V. Nguyen, H. T. Dang, L. D. Nguyen, H. V. Nguyen, H. T. Le, H. H. N. Nguyen, A. V. Nguyen, Y. H. Nguyen, V.-H. Nguyen, H.-H. Do, “Novel sulfonamide-functionalized arylidene indolones as potent α-glucosidase inhibitors: Synthesis, characterization, and in vitro and in silico studies”, Mendeleev Commun., 33:4 (2023), 543–545
Linking options:
https://www.mathnet.ru/eng/mendc454
https://www.mathnet.ru/eng/mendc/v33/i4/p543
This publication is cited in the following 1 articles:
N. I. Vikrishchuk, O. P. Demidov, O. I. Askalepova, L. D. Popov, Yu. I. Ryabukhin, “Crystal structure and properties of new benzimidazopyrido[2,3-b]indole-6-carbonitriles”, Mendeleev Commun., 34:2 (2024), 274–276
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