Abstract:
The large amount of data on enzyme structures obtained to date allow us to discuss general regularities in the formation of catalytic centres of enzymes. Approaches based on a comparison of structures in large data arrays made it possible to reveal a number of non-obvious regularities and to elicit principles of the design of catalytic centres
Document Type:
Article
Language: English
Citation:
S. D. Varfolomeev, “Catalytic centres of enzymes : structural paradoxes, the phenomenon of structural unity and new reactions”, Mendeleev Commun., 14:5 (2004), 185–188
Linking options:
https://www.mathnet.ru/eng/mendc3868
https://www.mathnet.ru/eng/mendc/v14/i5/p185
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Andrey do Nascimento Vieira, Karl Kleinermanns, William F. Martin, Martina Preiner, “The ambivalent role of water at the origins of life”, FEBS Letters, 594:17 (2020), 2717
S. D. Varfolomeev, S. V. Lushchekina, A. V. Nemukhin, “Computer simulation in molecular medicine and drug design”, Her. Russ. Acad. Sci., 86:3 (2016), 185
S. V. Lushchekina, I. A. Kaliman, B. L. Grigorenko, A. V. Nemukhin, S. D. Varfolomeev, “Quantum mechanical/molecular mechanical analysis of mechanisms of enzyme action. Human acetylcholinesterase”, Russ Chem Bull, 60:11 (2011), 2196
S. D. Varfolomeev, “Systemic approach in the physical and structural chemistry of enzyme catalysis: From primary structure to elementary event”, Kinet Catal, 48:4 (2007), 469
S. D. Varfolomeev, “Kinetic models of the prebiological evolution of macromolecules”, Mendeleev Commun., 17:1 (2007), 7–9
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