Abstract:
Tetraalkyl-substituted pyrazines were obtained by the multicomponent reaction of aliphatic linear nitriles with EtAlCl2 in the presence of Mg and Cp2TiCl2 catalyst in 60–91% yields. The same processing of isobutyronitrile gave 2,4,5-triisopropyl-1H-imidazole in 56% yield.
Keywords:
metal complex catalysis, dichlorobis(η5-cyclopentadienyl)titanium, ethylaluminum dichloride, nitriles, pyrazines, imidazoles.
Citation:
M. G. Shaibakova, N. A. Rikhter, L. K. Dil'mukhametova, I. R. Ramazanov, “Cp2TiCl2-catalyzed synthesis of tetraalkyl-substituted pyrazines by the reaction of nitriles with EtAlCl2 and Mg”, Mendeleev Commun., 33:2 (2023), 246–248
Linking options:
https://www.mathnet.ru/eng/mendc364
https://www.mathnet.ru/eng/mendc/v33/i2/p246
This publication is cited in the following 1 articles:
M. G. Shaibakova, E. I. Titova, L. K. Dil'mukhametova, I. R. Ramazanov, “Titanocene-catalyzed selective synthesis of 2,4-dialkyl-6-(2-methoxyethyl)pyridines by the reaction of terminal acetylenes with 3-methoxypropionitrile”, Russ Chem Bull, 73:8 (2024), 2211
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