Abstract:
Synthesis of a modified thymine monomer based on l-Glu, solid phase synthesis of anionic peptide nucleic acid (PNA) oligomers containing the modified monomer and optimization of the deblocking procedure and cleavage conditions of the PNA oligomers from resin are accomplished.
Citation:
A. V. Dezhenkov, M. V. Tankevich, E. D. Nikolskaya, I. P. Smirnov, G. E. Pozmogova, V. I. Shvets, Yu. G. Kirillova, “Synthesis of anionic peptide nucleic acid oligomers including γ-carboxyethyl thymine monomers”, Mendeleev Commun., 25:1 (2015), 47–48
Linking options:
https://www.mathnet.ru/eng/mendc2296
https://www.mathnet.ru/eng/mendc/v25/i1/p47
This publication is cited in the following 8 articles:
Stanley N. Oyaghire, Elias Quijano, J. Dinithi R. Perera, Hanna K. Mandl, W. Mark Saltzman, Raman Bahal, Peter M. Glazer, “DNA recognition and induced genome modification by a hydroxymethyl-γ tail-clamp peptide nucleic acid”, Cell Reports Physical Science, 4:10 (2023), 101635
Ahmed S. Abdelbaky, Ivan A. Prokhorov, Igor P. Smirnov, Kristina M. Koroleva, Vitaliy I. Shvets, Yulia G. Kirillova, “Synthesis of α-(R)-/γ-(S)-Dimethyl Substituted Peptide Nucleic Acid Submonomer Using Mitsunobu Reaction”, LOC, 16:5 (2019), 437
Ahmed S. Abdelbaky, Ivan A. Prokhorov, Elena V. Gnuskova, Olga V. Esipova, Yulia G. Kirillova, “Convenient and Efficient Syntheses of Peptide Nucleic Acid Purine Monomers”, COC, 23:19 (2019), 2122
Anna K. Manukyan, “Structural characteristics of cyclopentane-modified peptide nucleic acids from molecular dynamics simulations”, Struct Chem, 28:6 (2017), 1853
A.M. Varizhuk, A.V. Dezhenkov, Yu. G. Kirillova, Studies in Natural Products Chemistry, 47, 2016, 261
Yuliya Kirillova, Nataliya Boyarskaya, Andrey Dezhenkov, Mariya Tankevich, Ivan Prokhorov, Anna Varizhuk, Sergei Eremin, Dmitry Esipov, Igor Smirnov, Galina Pozmogova, Maxim Antopolsky, “Polyanionic Carboxyethyl Peptide Nucleic Acids (ce-PNAs): Synthesis and DNA Binding”, PLoS ONE, 10:10 (2015), e0140468
Iulia Sacui, Wei-Che Hsieh, Arunava Manna, Bichismita Sahu, Danith H. Ly, “Gamma Peptide Nucleic Acids: As Orthogonal Nucleic Acid Recognition Codes for Organizing Molecular Self-Assembly”, J. Am. Chem. Soc., 137:26 (2015), 8603
A. V. Dezhenkov, D. A. Cheshkov, I. A. Prokhorov, L. G. Dezhenkova, V. I. Shvets, Yu. G. Kirillova, “Regioselective alkylation of guanine derivatives in the synthesis of peptide nucleic acid monomers”, Russ Chem Bull, 64:5 (2015), 1100
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