Abstract:
An acid-catalyzed three-component reaction between hypophosphorous acid, aldehydes and alkyl carbamates under mild conditions afforded bis(α-aminoalkyl)phosphinic acids. The proposed facile single-stage protocol is prospective for expansion of a range of phosphinic analogues of HIV protease inhibitors.
Document Type:
Article
Language: English
Citation:
A. V. Vinyukov, A. V. Borodachev, A. S. Starikov, A. V. Afanasyev, M. E. Dmitriev, B. V. Lednev, V. V. Ragulin, “An efficient one-pot synthesis of bis(α-aminoalkyl)phosphinic acids, phosphorus-isosteric analogues of HIV protease inhibitors”, Mendeleev Commun., 28:3 (2018), 295–296
Linking options:
https://www.mathnet.ru/eng/mendc1743
https://www.mathnet.ru/eng/mendc/v28/i3/p295
This publication is cited in the following 3 articles:
Dmitry V. Moiseev, “Phospha-Mannich reactions of hypophosphorous acid H
3
PO
2”, Phosphorus, Sulfur, and Silicon and the Related Elements, 2025, 1
N. K. Gusarova, B. A. Trofimov, “Organophosphorus chemistry based on elemental phosphorus: advances and horizons”, Russian Chem. Reviews, 89:2 (2020), 225–249
N. K. Gusarova, A. O. Sutyrina, V. A. Kuimov, S. F. Malysheva, N. A. Belogorlova, P. A. Volkov, B. A. Trofimov, “Single-stage synthesis of alkyl-H-phosphinic acids from elemental phosphorus and alkyl bromides”, Mendeleev Commun., 29:3 (2019), 328–330
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