Abstract:
Four new tricyclic derivatives of 3,7-diazabicyclo[3.3.1]-nonane (bispidine) have been synthesized. In vitro patch clamp investigation has revealed for one of them the positive modulation of the kainate-induced AMPA receptor currents in a nanomolar concentration range, and for two other compounds the corresponding negative modulation has been demonstrated.
Citation:
M. I. Lavrov, P. N. Veremeeva, D. S. Karlov, V. L. Zamoyski, V. V. Grigoriev, V. A. Palyulin, “Tricyclic derivatives of bispidine as AMPA receptor allosteric modulators”, Mendeleev Commun., 29:6 (2019), 619–621
Linking options:
https://www.mathnet.ru/eng/mendc1607
https://www.mathnet.ru/eng/mendc/v29/i6/p619
This publication is cited in the following 15 articles:
E. A. Golubeva, M. I. Lavrov, P. N. Veremeeva, J. Matthews, E. V. Radchenko, V. L. Zamoyski, V. V. Grigoriev, V. A. Palyulin, Mendeleev Commun., 35:2 (2025), 142–144
Aleksei V. Medved'ko, Savelii V. Gaisen, Mikhail A. Kalinin, Sergey Z. Vatsadze, “Bispidine-Based Macrocycles: Achievements and Perspectives”, Organics, 4:3 (2023), 417
E. A. Golubeva, M. I. Lavrov, P. N. Veremeeva, E. M. Bovina, E. V. Radchenko, M. A. Topchiy, A. F. Asachenko, V. L. Zamoyski, V. V. Grigoriev, V. A. Palyulin, “New 1,11-dimethyl-3,6,9-triazatricyclo[7.3.1.13,11]tetradecane-4,8,12-trione derivative as an allosteric modulator of the glutamatergic system”, Mendeleev Commun., 33:1 (2023), 70–72
Dmitry P. Krut'ko, Alexey V. Medved'ko, Konstantin A. Lyssenko, Andrei V. Churakov, Alexander I. Dalinger, Mikhail A. Kalinin, Alexey O. Gudovannyy, Konstantin Y. Ponomarev, Eugeny V. Suslov, Sergey Z. Vatsadze, “Bispidine Platform as a Tool for Studying Amide Configuration Stability”, Molecules, 27:2 (2022), 430
Kseniya N. Sedenkova, Denis V. Zverev, Anna A. Nazarova, Mstislav I. Lavrov, Eugene V. Radchenko, Yuri K. Grishin, Alexey V. Gabrel'yan, Vladimir L. Zamoyski, Vladimir V. Grigoriev, Elena B. Averina, Vladimir A. Palyulin, “Novel Nanomolar Allosteric Modulators of AMPA Receptor of Bis(pyrimidine) Series: Synthesis, Biotesting and SAR Analysis”, Molecules, 27:23 (2022), 8252
Elena A. Golubeva, Mstislav I. Lavrov, Eugene V. Radchenko, Vladimir A. Palyulin, “Diversity of AMPA Receptor Ligands: Chemotypes, Binding Modes, Mechanisms of Action, and Therapeutic Effects”, Biomolecules, 13:1 (2022), 56
M. I. Lavrov, P. N. Veremeeva, E. A. Golubeva, E. V. Radchenko, V. L. Zamoyski, V. V. Grigoriev, V. A. Palyulin, “Positive and negative AMPA receptor modulators based on tricyclic bispidine derivative: Minor structural change inverts the type of activity”, Mendeleev Commun., 32:3 (2022), 360–363
E.V. Radchenko, A.S. Tarakanova, D.S. Karlov, M.I. Lavrov, V.A. Palyulin, “Ligands of the AMPA-subtype glutamate receptors: mechanisms of action and novel chemotypes”, BIOMED KHIM, 67:3 (2021), 187
Andrei V. Churakov, Aleksei V. Medved'ko, Petr V. Prikhodchenko, Dmitry P. Krut'ko, Sergey Z. Vatsadze, “First example of peroxosolvate of iodine-containing organic molecule”, Mendeleev Communications, 31:3 (2021), 352
Denis A. Borozdenko, Aiarpi A. Ezdoglian, Tatiana A. Shmigol, Darya I. Gonchar, Dmitri N. Lyakhmun, Dmitri V. Tarasenko, Yaroslav V. Golubev, Elvira A. Cherkashova, Daria D. Namestnikova, Ilya L. Gubskiy, Alexey A. Lagunin, Leonid V. Gubsky, Vladimir P. Chekhonin, Sophia S. Borisevich, Maxim A. Gureev, Anastasia D. Shagina, Nina M. Kiseleva, Vadim V. Negrebetsky, Yuri I. Baukov, “A Novel Phenylpyrrolidine Derivative: Synthesis and Effect on Cognitive Functions in Rats with Experimental Ishemic Stroke”, Molecules, 26:20 (2021), 6124
Dmitry A. Vasilenko, Kirill S. Sadovnikov, Kseniya N. Sedenkova, Dmitry S. Karlov, Eugene V. Radchenko, Yuri K. Grishin, Victor B. Rybakov, Tamara S. Kuznetsova, Vladimir L. Zamoyski, Vladimir V. Grigoriev, Vladimir A. Palyulin, Elena B. Averina, “A Facile Approach to Bis(isoxazoles), Promising Ligands of the AMPA Receptor”, Molecules, 26:21 (2021), 6411
N. S. Temnyakova, D. A. Vasilenko, M. I. Lavrov, D. S. Karlov, Yu. K. Grishin, V. L. Zamoyski, V. V. Grigoriev, E. B. Averina, V. A. Palyulin, “Novel bivalent positive allosteric AMPA receptor modulator of bis-amide series”, Mendeleev Commun., 31:2 (2021), 216–218
N. S. Temnyakova, D. A. Vasilenko, M. I. Lavrov, D. S. Karlov, Yu. K. Grishin, V. L. Zamoyski, V. V. Grigoriev, E. B. Averina, V. A. Palyulin, “New nanomolar negative modulators of AMPA receptors”, Mendeleev Commun., 31:2 (2021), 219–220
I. Yu. Titov, V. S. Stroylov, P. V. Rusina, I. Svitanko, “Preliminary modelling as the first stage of targeted organic synthesis”, Russian Chem. Reviews, 90:7 (2021), 831–867
S. Z. Vatsadze, A. V. Medved'ko, A. A. Bodunov, K. A. Lyssenko, “Bispidine-based bis-azoles as a new family of supramolecular receptors: the theoretical approach”, Mendeleev Commun., 30:3 (2020), 344–346
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