Abstract:
New lipophilic polyamines in which natural or synthetic tetraamines were linked via the terminal NH2 groups to diglycerides and/or to short-chained aliphatic substituents were synthesized, and their cytotoxic activity was tested. Relationship between the structure of the synthesized compounds and their cytotoxicity and hemolytic effect was evaluated.
Citation:
K. A. Perevoshchikova, A. I. Nichugovskiy, A. K. Isagulieva, N. G. Morozova, I. V. Ivanov, M. A. Maslov, A. A. Shtil, “Synthesis of novel lipophilic tetraamines with cytotoxic activity”, Mendeleev Commun., 29:6 (2019), 616–618
Linking options:
https://www.mathnet.ru/eng/mendc1606
https://www.mathnet.ru/eng/mendc/v29/i6/p616
This publication is cited in the following 9 articles:
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Ksenia A. Perevoshchikova, Elizaveta A. Eshtukova-Shcheglova, Oleg V. Markov, Andrey V. Markov, Ivan V. Chernikov, Mikhail A. Maslov, Marina A. Zenkova, “Symmetric lipophilic polyamines exhibiting antitumor activity”, Bioorganic & Medicinal Chemistry, 76 (2022), 117089
E. A. Eshtukova-Shcheglova, K. A. Perevoshchikova, A. V. Eshtukov-Shcheglov, D. A. Cheshkov, M. A. Maslov, “Amination of epoxides as a convenient approach for lipophilic polyamines synthesis”, Fine Chem. Technol., 17:4 (2022), 323
Artemiy Nichugovskiy, Gian Tron, Mikhail Maslov, “Recent Advances in the Synthesis of Polyamine Derivatives and Their Applications”, Molecules, 26:21 (2021), 6579
A. I. Nichugovskiy, A. A. Khrulev, K. A. Perevoshchikova, D. A. Cheshkov, N. G. Morozova, M. A. Maslov, “Synthesis of Isonitrile Derivatives of Diglycerides and Carbohydrates as Intermediates for Multicomponent Ugi Reaction”, Russ J Bioorg Chem, 47:4 (2021), 929
E. A. Varlamova, A. K. Isagulieva, N. G. Morozova, E. V. Shmendel, M. A. Maslov, A. A. Shtil, “Non-Phosphorus Lipids As New Antitumor Drug Prototypes”, Russ J Bioorg Chem, 47:5 (2021), 965
A. Nichugovskiy, M. Maslov, “APPLICATION OF A MULTICOMPONENT UGI REACTION FOR SYNTHESIS OF LIPOPHILIC POLYAMINES”, BIOTECHNOLOGY: STATE OF THE ART AND PERSPECTIVES, 2020, 65
K. Perevoshchikova, E. Shcheglova, D. Makarova, P. Puchkov, E. Shmendel, M. Maslov, “CYTOTOXICITY AND MICELLAR PROPERTIES OF SYMMETRIC LIPOPHILIC POLYAMINES”, BIOTECHNOLOGY: STATE OF THE ART AND PERSPECTIVES, 2020, 165
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