Abstract:
The study presents the results of analysis of protein sequence database for prokaryotic microorganisms, which revealed a conservative peptide sequence element of 11 amino acid residues in 20 loci of 16 functionally and phylogenetically differing conservative proteins from representatives of various taxa. This amino acid motif IKAVRELGLER is presumably one of the Last Universal Peptide Ancestors (LUPAs). A fragment of ribosomal RNA (part of the A-site including stems H92, H90 and H93 of the peptidyl transferase center, PTC) translated from one of the potential reading frames is likely to be a source of genetic information for this sequence. We define this m/rRNA fragment with a function of a template for LUPA synthesis as the Last Universal RiboNucleic Ancestor (LURNA). We assume that LURNA and the peptides translated from its sequence were a source of the modern diversity of peptides.
Key words:
ribosome, ribosomal RNA, translation, peptidyl transferase center, universal peptide motif, Last Universal Peptide Ancestor, LUPA, Last Universal RiboNucleic Ancestor, LURNA.
Citation:
N. E. Skoblikov, A. A. Zimin, “A search for relict ribonucleotide and amino acid sequences that played a key role in the development of the ribosome and modern protein diversity”, Mat. Biolog. Bioinform., 10:1 (2015), 116–130
\Bibitem{SkoZim15}
\by N.~E.~Skoblikov, A.~A.~Zimin
\paper A search for relict ribonucleotide and amino acid sequences that played a key role in the development of the ribosome and modern protein diversity
\jour Mat. Biolog. Bioinform.
\yr 2015
\vol 10
\issue 1
\pages 116--130
\mathnet{http://mi.mathnet.ru/mbb215}
\crossref{https://doi.org/10.17537/2015.10.116}
This publication is cited in the following 4 articles:
N. N. Nazipova, “Raznoobrazie nekodiruyuschikh RNK v genomakh eukariot”, Matem. biologiya i bioinform., 16:2 (2021), 256–298
Nikolai E. Skoblikow, Andrei A. Zimin, “Mineral Grains, Dimples, and Hot Volcanic Organic Streams: Dynamic Geological Backstage of Macromolecular Evolution”, J Mol Evol, 86:3-4 (2018), 172
Nikolai E. Skoblikow, Andrei A. Zimin, “Hypothesis of Lithocoding: Origin of the Genetic Code as a “Double Jigsaw Puzzle” of Nucleobase-Containing Molecules and Amino Acids Assembled by Sequential Filling of Apatite Mineral Cellules”, J Mol Evol, 82:4-5 (2016), 163
V. S. Bystrov, E. V. Paramonova, A. V. Bystrova, V. E. Gevorkyan, X. J. Meng, B. B. Tian, J. L. Wang, L. A. Avakyan, “Analiz vychislitelnykh i eksperimentalnykh issledovanii pereklyucheniya polyarizatsii v PVDF i P (VDF-TrFE) segnetoelektricheskikh plenkakh na nanourovne”, Matem. biologiya i bioinform., 10:2 (2015), 372–386
Citation in format AMSBIB
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