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Эта публикация цитируется в 1 научной статье (всего в 1 статье)
Нанофотоника International Conference ''PCNSPA 2018 -- Photonic Colloidal Nanostructures: Synthesis, Properties, and Applications'', Saint Petersburg, Russia, June 4--8, 2018
Advanced nanotools for imaging of solid tumors and circulating and disseminated cancer cells
A. Sukhanovaab, F. Ramos-Gomesc, F. Alvescd, P. Chamesef, D. Batyef, I. Nabievab a Laboratory of Nano-Bioengineering, National Research Nuclear University MEPhI (Moscow Engineering Physics Institute),
115409 Moscow, Russia
b Laboratoire de Recherche en Nanosciences, LRN-EA4682, Université de Reims Champagne–Ardenne, 51100 Reims, France
c Translational Molecular Imaging Unit, Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany
d Clinic of Haematology and Medical Oncology, University Medical Center Göttingen, Georg-August-Universität, 37075 Göttingen, Germany
e Aix-Marseille Université, 13009 Marseille, France
f Centre de Recherche en Cancérologie de Marseille, 13009 Marseille, France
Аннотация:
Semiconductor quantum dots (QDs) are characterized by orders of magnitude higher multiphoton linear absorption cross-sections compared with conventional organic dyes. Combined with the QD photoluminescence quantum yield approaching 100% and their rock-solid photostability, this fact opens great prospects for the two-photon functional tumor imaging with QDs tagged with highly specific recognition molecules. Single-domain antibodies (sdAbs) or “nanobodies” derived from lamas are the smallest high-affinity recognition molecules, which may be tagged with the QDs thus permitting not only solid tumors multiphoton imaging but also rare disseminated cancer cells and micrometastases in the depth of the tissue to be detected.
Поступила в редакцию: 06.07.2018
Образец цитирования:
A. Sukhanova, F. Ramos-Gomes, F. Alves, P. Chames, D. Baty, I. Nabiev, “Advanced nanotools for imaging of solid tumors and circulating and disseminated cancer cells”, Оптика и спектроскопия, 125:5 (2018), 655; Optics and Spectroscopy, 125:5 (2018), 703–707
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/os852 https://www.mathnet.ru/rus/os/v125/i5/p655
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