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Эта публикация цитируется в 4 научных статьях (всего в 4 статьях)
CHEMISTRY AND MATERIAL SCIENCE
Antibacterial activity of Amikacin-immobilized detonation nanodiamond
A. S. Solomatinab, R. Yu. Yakovlevabc, O. V. Efremenkovad, I. G. Sumarukovad, I. I. Kulakovab, G. V. Lisichkinb a Ryazan State Medical University, Ryazan, Russia
b Lomonosov Moscow State University
c Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences, Moscow
d Gause Institute of New Antibiotics, Moscow, Russia
Аннотация:
Detonation nanodiamonds (NDs) with chlorinated (ND-Cl) and carboxylated (ND-COOH) surfaces were obtained. The broad-spectrum antibiotic Amikacin (Amik) was covalently grafted to the chlorinated surface (ND-Amik) and immobilized by adsorption to carboxylated surface (Amik/ND-COOH). Biological testing in vitro showed the presence of antibacterial activity of the obtained samples against Staphylococcus aureus FDA P209 and Escherichia coli ATCC 25922, close to activity of free amikacin. It was revealed that to maintain antibacterial activity of the samples after their preliminary treatment, important factors such as the use of antioxidants (hydrosulfite and sodium citrate) and lyophilization were necessary.
Ключевые слова:
detonation nanodiamond (ND), amikacin (Amik), lyophilization, antioxidants, antibacterial activity.
Поступила в редакцию: 27.05.2017 Исправленный вариант: 03.07.2017
Образец цитирования:
A. S. Solomatin, R. Yu. Yakovlev, O. V. Efremenkova, I. G. Sumarukova, I. I. Kulakova, G. V. Lisichkin, “Antibacterial activity of Amikacin-immobilized detonation nanodiamond”, Наносистемы: физика, химия, математика, 8:4 (2017), 531–534
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/nano70 https://www.mathnet.ru/rus/nano/v8/i4/p531
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Страница аннотации: | 67 | PDF полного текста: | 42 |
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