Аннотация:
Detonation nanodiamonds (NDs) with chlorinated (ND-Cl) and carboxylated (ND-COOH) surfaces were obtained. The broad-spectrum antibiotic Amikacin (Amik) was covalently grafted to the chlorinated surface (ND-Amik) and immobilized by adsorption to carboxylated surface (Amik/ND-COOH). Biological testing in vitro showed the presence of antibacterial activity of the obtained samples against Staphylococcus aureus FDA P209 and Escherichia coli ATCC 25922, close to activity of free amikacin. It was revealed that to maintain antibacterial activity of the samples after their preliminary treatment, important factors such as the use of antioxidants (hydrosulfite and sodium citrate) and lyophilization were necessary.
This study has been performed with support from the grant of Russian Science Foundation (project 16-08-01156).
Поступила в редакцию: 27.05.2017 Исправленный вариант: 03.07.2017
Реферативные базы данных:
Тип публикации:
Статья
PACS:68.35.-p, 7.85.Tu
Язык публикации: английский
Образец цитирования:
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I. L. Plastun, A. N. Bokarev, A. A. Zakharov, A. A Naumov, “Supramolecular interaction of modificated nanodiamonds, biomolecules and drugs: molecular modeling”, Fullerenes, Nanotubes and Carbon Nanostructures, 28:3 (2020), 183
R. Yu. Yakovlev, P. G. Mingalev, N. B. Leonidov, G. V. Lisichkin, “Detonation Nanodiamonds as Promising Drug Carriers”, Pharm Chem J, 54:4 (2020), 389
I.L. Plastun, A.N. Bokarev, 2019 IEEE 8th International Conference on Advanced Optoelectronics and Lasers (CAOL), 2019, 93
А. Н. Бокарев, И. Л. Пластун, “Межмолекулярное взаимодействие в двухкомпонентных смесях наноалмазов и доксорубицина”, Изв. Сарат. ун-та. Нов. cер. Сер. Физика, 18:3 (2018), 177–188