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Эта публикация цитируется в 6 научных статьях (всего в 6 статьях)
CHEMISTRY AND MATERIAL SCIENCE
CeO$_{2}$ nanoparticles as free radical regulators in biological systems
M. M. Sozarukovaa, E. V. Proskurninab, A. Y. Baranchikova, V. K. Ivanova a Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninsky Prospect, 31, Moscow, 119991, Russia
b Research Centre for Medical Genetics, Moskvorechie St, 1, Moscow, 115522, Russia
Аннотация:
Cerium dioxide nanoparticles possess unique physical and chemical properties, among which the enzyme-like activity is of particular interest. In particular, they are able to perform the functions of pro- and antioxidant enzymes, such as superoxide dismutase (SOD), catalase, and peroxidase. Due to the advantages associated with pH and temperature stability and low cost, CeO$_{2}$ nanoparticles can be considered as promising mimetics of these enzymes. In this paper, the antioxidant activity of a citrate-stabilized colloidal suspension of CeO$_{2}$ nanoparticles has been studied using chemiluminometry in model systems generating superoxide anion radical and hydrogen peroxide. In the lucigenin/xanthine/xanthine oxidase system, generating a superoxide anion radical, CeO$_{2}$ nanoparticles exhibit antioxidant properties increasing upon conjugation with SOD. When interacting with hydrogen peroxide, CeO$_{2}$ nanoparticles exhibit peroxidase-like activity. In the combined ROS generating system, lucigenin/Co(II)/H$_{2}$O$_{2}$, CeO$_{2}$ nanoparticles demonstrated prooxidant activity.
Ключевые слова:
cerium dioxide nanoparticles, superoxide anion radical, hydrogen peroxide, nanozymes, superoxide dismutase, peroxidase, chemiluminescence.
Поступила в редакцию: 19.02.2020
Образец цитирования:
M. M. Sozarukova, E. V. Proskurnina, A. Y. Baranchikov, V. K. Ivanov, “CeO$_{2}$ nanoparticles as free radical regulators in biological systems”, Наносистемы: физика, химия, математика, 11:3 (2020), 324–332
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/nano531 https://www.mathnet.ru/rus/nano/v11/i3/p324
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Страница аннотации: | 92 | PDF полного текста: | 42 |
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