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Эта публикация цитируется в 1 научной статье (всего в 1 статье)
CHEMISTRY AND MATERIAL SCIENCE
Cytotoxicity analysis of gadolinium doped cerium oxide nanoparticles on human mesenchymal stem cells
A. L. Popova, I. V. Savintsevaa, E. A. Mysinaa, A. B. Shcherbakovb, N. R. Popovaa, O. S. Ivanovac, D. D. Kolmanovichd, V. K. Ivanovce a Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences,
Pushchino, Moscow region, 142290, Russia
b Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine,
Kyiv D0368, Ukraine
c Kurnakov Institute of General and Inorganic Chemistry of Russian Academy of Sciences,
Moscow 119991, Russia
d Kabardino-Balkarian
State University, Nalchik, 360004, Russia
e Moscow Technological University, Institute of Fine Chemical Technologies, Moscow 119991, Russia
Аннотация:
A complex analysis of cytotoxicity was performed for a nanodispersed sol of cerium dioxide doped with gadolinium (Ce$_{0.8}$Gd$_{0.2}$O$_{2-x}$) using a culture of mesenchymal stem cells. The absence of cyto- and genotoxicity over a wide range of concentrations ($10^{-5} - 10^{-9}$ M) was demonstrated. At that, the highest concentration of Ce$_{0.8}$Gd$_{0.2}$O$_{2-x}$ nanoparticles ($10^{-4}$ M) was found to slightly reduce the activity of intracellular dehydrogenase, yet not leading to the development of apoptosis and further cell death. The obtained results confirm a high degree of Ce$_{0.8}$Gd$_{0.2}$O$_{2-x}$ nanoparticle biocompatibility, which opens prospects for their safe application as a contrasting agent in the magnetic resonance tomography.
Ключевые слова:
ceria, gadolinium, nanomaterials, cytotoxicity, mesenchymal stem cells.
Поступила в редакцию: 22.03.2018
Образец цитирования:
A. L. Popov, I. V. Savintseva, E. A. Mysina, A. B. Shcherbakov, N. R. Popova, O. S. Ivanova, D. D. Kolmanovich, V. K. Ivanov, “Cytotoxicity analysis of gadolinium doped cerium oxide nanoparticles on human mesenchymal stem cells”, Наносистемы: физика, химия, математика, 9:3 (2018), 430–438
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/nano327 https://www.mathnet.ru/rus/nano/v9/i3/p430
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