Аннотация:
A series of novel conjugates of 4-amino-2,3-polymethylene quinolines and phenolic antioxidant vanillin was synthesized by the condensation of aminoquinolines with vanillin followed by reduction of imines with sodium borohydride. The conjugates effectively inhibit AChE and BChE with preferable BChE inhibition and displace propidium from the PAS AChE. Compounds with aminoalkyl spacer have preferable esterase profile being more potent cholinesterases inhibitors with lower anti-CES activity and are the most potent antioxidants in ABTS and FRAP tests.
Образец цитирования:
G. F. Makhaeva, I. V. Serkov, N. V. Kovaleva, E. V. Rudakova, N. P. Boltneva, E. A. Kochetkova, A. N. Proshin, S. O. Bachurin, “Novel conjugates of 4-amino-2,3-polymethylenequinolines and vanillin as potential multitarget agents for AD treatment”, Mendeleev Commun., 31:5 (2021), 606–608
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc997
https://www.mathnet.ru/rus/mendc/v31/i5/p606
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I. V. Serkov, A. N. Proshin, N. V. Kovaleva, N. P. Boltneva, E. V. Rudakova, G. F. Makhaeva, S. O. Bachurin, “Synthesis and properties of new derivatives of 4-amino-2,3-polymethylenequinolines with antioxidant function”, Russ Chem Bull, 72:3 (2023), 802
Lucia Zakharova, Gulnara Gaynanova, Elmira Vasilieva, Leysan Vasileva, Rais Pavlov, Ruslan Kashapov, Konstantin Petrov, Oleg Sinyashin, “Recent Nanoscale Carriers for Therapy of Alzheimer's Disease: Current Strategies and Perspectives”, CMC, 30:33 (2023), 3743
I. I. Islamov, A. V. Yusupova, V. A. D'yakonov, U. M. Dzhemilev, “Synthesis of new ionic liquids based on (5Z,9Z)-alkadienoic acids and choline”, Mendeleev Commun., 33:1 (2023), 50–52
Galina F. Makhaeva, Nadezhda V. Kovaleva, Natalia P. Boltneva, Elena V. Rudakova, Sofya V. Lushchekina, Tatiana Yu. Astakhova, Igor V. Serkov, Alexey N. Proshin, Eugene V. Radchenko, Vladimir A. Palyulin, Jan Korabecny, Ondrej Soukup, Sergey O. Bachurin, Rudy J. Richardson, “Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: N-Functionalization Determines the Multitarget Anti-Alzheimer's Activity Profile”, Molecules, 27:3 (2022), 1060
Igor Yu. Grishin, Vladimir V. Malyuga, Dmitrii А. Aksenov, Nikita K. Kirilov, Gasan M. Abakarov, Sergei N. Ovcharov, Andrei V. Sarapii, Nikolai А. Aksenov, Alexander V. Aksenov, “A sequence of acylamination and acylation reactions in polyphosphoric acid – a novel approach to the Friedländer synthesis of 2-arylquinolines”, Chem Heterocycl Comp, 58:6-7 (2022), 313
Maria V. Grishchenko, Galina F. Makhaeva, Yanina V. Burgart, Elena V. Rudakova, Natalia P. Boltneva, Nadezhda V. Kovaleva, Olga G. Serebryakova, Sofya V. Lushchekina, Tatiana Y. Astakhova, Ekaterina F. Zhilina, Evgeny V. Shchegolkov, Rudy J. Richardson, Victor I. Saloutin, “Conjugates of Tacrine with Salicylamide as Promising Multitarget Agents for Alzheimer's Disease”, ChemMedChem, 17:10 (2022)
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