Аннотация:
The supramolecular complexation of anthracycline antibiotic ruboxyl with water-soluble fullerene derivative was visualized by scattering scanning near-field optical microscopy, and the effects of this complexation on the antileukemic activity in vivo were evaluated. Treatment of mice with P388 lymphocytic leukemia with ruboxyl resulted in 13% of cured animals, while similar treatment with ruboxyl–fullerene derivative combination caused 63% curing.
Ключевые слова:
water-soluble fullerene derivative, ruboxyl, leukemia, vesicles, IR s-SNOM.
Образец цитирования:
O. A. Kraevaya, E. A. Khakina, N. A. Emelianov, A. F. Shestakov, T. E. Sashenkova, D. V. Mishchenko, P. A. Troshin, “Integration of anticancer drug ruboxyl into the membrane of fullerene-based vesicle enhances its therapeutic performance”, Mendeleev Commun., 34:2 (2024), 178–180
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc75
https://www.mathnet.ru/rus/mendc/v34/i2/p178
Эта публикация цитируется в следующих 2 статьяx:
Olga Bolshakova, Olga Zherebyatieva, Svetlana V. Sarantseva, “Fullerenes in vivo. Toxicity and protective effects”, Nanotoxicology, 2025, 1
D. A. Poletaeva, A. V. Smolina, V. N. Varfolomeev, N. N. Lashmanov, E. N. Klimanova, E. A. Khakina, O. A. Kraevaya, P. A. Troshin, I. I. Faingold, “Influence of Fullerene–Ruboxyl Dyad on Markers of Mitochondrial Dysfunction In Vitro”, Nanotechnol Russia, 19:3 (2024), 461