Аннотация:
Noncatalytic on water aldol transformation of isatins and cyclic 1,3-diketones results in substituted 3-hydroxy-3-(2-hydroxy-6-oxocyclohex-1-en-1-yl)indolin-2-ones in 87–98% yields. Optimized conditions have been found and a mechanistic rationale for the reaction has been deduced. The new efficient and facile process represents a convenient way to compounds with the 3-hydroxyindolin-2-one and 3-hydroxycyclohex-2-en-1-one moieties.
Ключевые слова:
aldol reaction, noncatalytic, on water, isatin, 13-diketone, 3-hydroxyindolin-2-one.
Образец цитирования:
M. N. Elinson, Yu. E. Ryzhkova, V. M. Kalashnikova, M. P. Egorov, “Noncatalytic on water aldol reaction of isatins with cyclic 1,3-diketones at room temperature without the need for subsequent chromatography”, Mendeleev Commun., 32:4 (2022), 543–545
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc720
https://www.mathnet.ru/rus/mendc/v32/i4/p543
Эта публикация цитируется в следующих 2 статьяx:
M. N. Elinson, Yu. E. Ryzhkova, V. M. Kalashnikova, A. O. Chizhov, A. N. Fakhrutdinov, M. P. Egorov, “First example of isatin used in four-component synthesis of ionic unsymmetrical scaffold with three different heterocyclic rings”, Mendeleev Commun., 34:6 (2024), 865–867
Yuliya E. Ryzhkova, Fedor V. Ryzhkov, Michail N. Elinson, “Triethylammonium 2-(3-Hydroxy-2-oxoindolin-3-yl)-5,5-dimethyl-3-oxocyclohex-1-en-1-olate”, Molbank, 2023:1 (2023), M1589
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