Аннотация:
A new monoterpene–azole hybrid containing myrtenyl- bispidine moiety, 2-(2,4-difluorophenyl)-1-(7-{[(1R,5S)-6,6- dimethylbicyclo[3.1.1]hept-2-en-2-yl]methyl}-1,5-dimethyl- 3,7-diazabicyclo[3.3.1]non-3-yl)-3-(1H-1,2,4-triazol-1-yl)- propan-2-ol was prepared in six steps with 55% overall yield. The compound was tested against a number of Candida spp. fungi and found to be active against Candida albicans. Molecular docking suggested possible inhibition of lanosterol 14α-demethylase (CYP51), a membrane enzyme targeted by azole antifungals.
Образец цитирования:
N. S. Li-Zhulanov, K. Yu. Ponomarev, S. Sari, D. Gülmez, S. Arikan-Akdagli, V. I. Krasnov, E. V. Suslov, K. P. Volcho, N. F. Salakhutdinov, “Myrtenyl-bispidine containing azole: synthesis and antifungal activity”, Mendeleev Commun., 34:1 (2024), 119–121
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc61
https://www.mathnet.ru/rus/mendc/v34/i1/p119
Эта публикация цитируется в следующих 2 статьяx:
Alan Akhmedov, Rustem Gamirov, Yulia Panina, Alina Baklagina, Evgenia Sokolova, Pavel Zelenikhin, Olga Babaeva, Vasily Babaev, Dmitriy Shurpik, Ivan Stoikov, “Cationic amphiphilic meroterpenoids: synthesis, antibacterial, antifungal and mutagenic activity”, Chim.Tech.Acta, 11:2 (2024)
Yusuf Ataker, Özge Öncü, Dolunay Gülmez, Suna Sabuncuoğlu, Sevtap Arikan‐Akdagli, Suat Sari, “New Ester‐Containing Azole Derivatives With Potent Anti‐Candida Effects: Synthesis, Antifungal Susceptibility, Cytotoxicity, and Molecular Modeling Studies”, Drug Development Research, 85:7 (2024)
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