Synthesis of 1,4,2,6-dithiadiazinane 1,1-dioxide and study of its cytotoxic activity

Cyclothiomethylation of sulfamide using paraformaldehyde or bis(dimethylamino)methane, hydrogen sulfide or its sodium salts catalyzed by rare-earth salts affords 1,4,2,6-dithiadi azinane 1,1-dioxide. The heterocycle was found to exhibit a pronounced cytotoxic effect against suspension tumor cell lines (Jurkat, HL60, K562, and U937).