Аннотация:
The disodium salt of (4R,5R)-(TADDOL), 3, can be used as a mediator in the asymmetric Michael reaction, e.g. 1,4-addition of a glycine synthon 1 to methyl methacrylate 2, mediated by 3 (10–100 mol%), gives a diastereoisomeric excess of the corresponding product 4 up to 65% and an enantiomeric purity ca. 28%; (2S,4R)-4-methylglutamic acid (ee ≥ 85%), 6, was obtained starting from (2S,4R)-4 (ee 28%) through the recrystallization and decomposition of the latter.
Тип публикации:
Статья
Язык публикации: английский
Образец цитирования:
Yu. N. Belokon, K. A. Kochetkov, T. D. Churkina, N. S. Ikonnikov, S. A. Orlova, V. V. Smirnov, A. A. Chesnokov, “Asymmetric Michael addition of a glycine synthon to methyl methacrylate, mediated by disodium TADDOLate”, Mendeleev Commun., 7:4 (1997), 137–138
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc4823
https://www.mathnet.ru/rus/mendc/v7/i4/p137
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Yuri N Belokon', Konstantin A Kochetkov, Tatiana D Churkina, Nikolai S Ikonnikov, Alexey A Chesnokov, Oleg V Larionov, Virinder S Parmár, Rajesh Kumar, Henri B Kagan, “Asymmetric PTC C-alkylation mediated by TADDOL—novel route to enantiomerically enriched α-alkyl-α-amino acids”, Tetrahedron: Asymmetry, 9:5 (1998), 851
Y. N. BELOKON', K. A. KOCHETKOV, T. D. CHURKINA, N. S. IKONNIKOV, S. A. ORLOVA, V. V. SMIRNOV, A. A. CHESNOKOV, “ChemInform Abstract: Asymmetric Michael Addition of a Glycine Synthon to Methyl Methacrylate, Mediated by Disodium TADDOLate.”, ChemInform, 28:49 (1997)
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