Эта публикация цитируется в 1 научной статье (всего в 1 статье)
Communications
Novel sulfonamide-functionalized arylidene indolones as potent α-glucosidase inhibitors: Synthesis, characterization, and in vitro and in silico studies
aHanoi University of Pharmacy, Phan Chu Trinh, Hoan Kiem, Hanoi, Vietnam bNguyen Gia Thieu High School, Long Bien, Gia Lam, Hanoi, Vietnam cFaculty of Chemistry, University of Science, Vietnam National University, Hanoi, Hoan Kiem, Hanoi, Vietnam
Аннотация:
3-Arylidene-1-(2,6-dichlorophenyl)indolones and in particular their 5-methylaminosulfonyl derivatives efficiently inhibit α-glucosidase enzyme. The results are corroborated by in silico docking studies which show the binding of aminosulfonyl derivatives to be more favorable due to additional hydrogen bonding. The most active compound of the series shows the IC50 of 6.19 μm.
Образец цитирования:
G. V. Nguyen, H. T. Dang, L. D. Nguyen, H. V. Nguyen, H. T. Le, H. H. N. Nguyen, A. V. Nguyen, Y. H. Nguyen, V.-H. Nguyen, H.-H. Do, “Novel sulfonamide-functionalized arylidene indolones as potent α-glucosidase inhibitors: Synthesis, characterization, and in vitro and in silico studies”, Mendeleev Commun., 33:4 (2023), 543–545
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc454
https://www.mathnet.ru/rus/mendc/v33/i4/p543
Эта публикация цитируется в следующих 1 статьяx:
N. I. Vikrishchuk, O. P. Demidov, O. I. Askalepova, L. D. Popov, Yu. I. Ryabukhin, “Crystal structure and properties of new benzimidazopyrido[2,3-b]indole-6-carbonitriles”, Mendeleev Commun., 34:2 (2024), 274–276
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