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Эта публикация цитируется в 3 научных статьях (всего в 3 статьях)
Synthesis of new analgesics based on 4-isopropyl-1-phenyl-3-(trifluoromethyl)pyrazol-5-one
L. S. Lapshina, E. V. Shchegolkova, Ya. V. Burgarta, G. A. Triandafilovab, O. P. Krasnykhb, Рљ. O. Malyshevab, V. I. Saloutina a I.Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation
b Perm National Research Polytechnic University, Perm, Russian Federation
Аннотация:
Methyl 4-trifluoro-2-isopropyl-4-oxobutanoate prepared by the improved procedure was cyclized with hydrazines to afford the title pyrazole derivatives. N- and O-alkylation of 4-isopropyl-1-phenyl-3-(trifluoromethyl)pyrazol-5-ol gave trifluoromethyl analogues of Propyphenazone and 5-alkoxy derivatives. 4-Isopropylpyrazoles containing O-butoxy moiety with a terminal trifluoromethyl or acyloxy group were found to demonstrate a promising analgesic activity.
Ключевые слова:
4-isopropyl-3-(trifluoromethyl)pyrazol-5-ols, alkylation, propyphenazone, 5-alkoxypyrazoles, organofluorine compounds,
analgesic activity, acute toxicity.
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc347
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