Аннотация:
Novel organotin(iv) complexes based on anticancer drug abiraterone acetate and abiraterone incorporating semipolar N→Sn bond at the pyridine moiety were synthesized and characterized. In vitro antiproliferative activity of the complexes against human cancer and normal cell lines was evaluated, the complexes with triphenyltin moiety being the most active (IC50 is in the range of 120–430 nm). Compounds actively induced apoptosis and blocked proliferation in the G2/M phase of the cell cycle.
Образец цитирования:
D. B. Shpakovsky, D. A. Berseneva, Yu. A. Gracheva, T. A. Antonenko, Yu. F. Oprunenko, V. V. Britikov, E. V. Britikova, E. R. Milaeva, “Synthesis and antiproliferative activity of novel organotin complexes bearing abiraterone drug moiety”, Mendeleev Commun., 34:1 (2024), 22–24
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc32
https://www.mathnet.ru/rus/mendc/v34/i1/p22
Эта публикация цитируется в следующих 3 статьяx:
Wujiu Jiang, Qing Luo, Wei Huang, Yuxing Tan, Yiyuan Peng, “Synthesis, anticancer activity, and mechanistic investigations of aryl-alkyl diorganotin arylformylhydrazone complexes”, Journal of Inorganic Biochemistry, 262 (2025), 112756
Xinhua Wu, Lifang Wu, Zhaoquan Li, Wei Tian, Tao Li, “Synthesis, crystal structure, and anticancer activity of organotin(IV) complexes based on chlorine substituted aryl ligands”, Med Chem Res, 2025
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