Аннотация:
To enhance the lipophilicity of the NO-synthase inhibitor 2-amino-5,6-dihydro-4H-1,3-thiazine, its bridgehead analogue was suggested on the basis of molecular modeling; the synthetic routes to new 3-thia-1-azabicyclo[3.3.1]nonane derivatives and the results of their biological testing are presented.
Образец цитирования:
O. N. Zefirova, E. V. Nurieva, V. I. Chupakhin, I. S. Semenova, D. I. Peregud, M. V. Onufriev, N. V. Gulyaeva, “Design, synthesis and biotest of a bicyclo[3.3.1]nonane analogue of 2-amino-5,6-dihydro-4H-1,3-thiazine”, Mendeleev Commun., 20:6 (2010), 323–325
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc3080
https://www.mathnet.ru/rus/mendc/v20/i6/p323
Эта публикация цитируется в следующих 18 статьяx:
Hong Qin, Man Yang, Yuguang Li, Xiaobing Yang, Yujing Hu, Chengkou Liu, Wei He, Zheng Fang, Kai Guo, “Synthesis of bridged bicyclic thiazine-2-thione and thiazole-2-thiones through DBU-promoted regioselective annulation of quinone monoacetals under mild conditions”, Green Synthesis and Catalysis, 2024
Nilmadhab Roy, Rishav Das, Rupankar Paira, Priyankar Paira, “Different routes for the construction of biologically active diversely functionalized bicyclo[3.3.1]nonanes: an exploration of new perspectives for anticancer chemotherapeutics”, RSC Adv., 13:32 (2023), 22389
Barbara Parrino, Stella Cascioferro, Daniela Carbone, Camilla Pecoraro, Girolamo Cirrincione, Patrizia Diana, Advances in Heterocyclic Chemistry, 136, 2022, 1
Barbara Parrino, Stella Cascioferro, Daniela Carbone, Girolamo Cirrincione, Patrizia Diana, Comprehensive Heterocyclic Chemistry IV, 2022, 150
Evgeniya V. Nurieva, Alexander A. Alexeev, Olga N. Zefirova, “Cyclic Isothiourea in Drug Design”, Chem Heterocycl Comp, 57:9 (2021), 889
E. V. Nurieva, T. P. Trofimova, A. A. Alexeev, A. N. Proshin, E. A. Chesnakova, Yu. K. Grishin, K. A. Lyssenko, M. V. Filimonova, S. O. Bachurin, O. N. Zefirova, “Synthesis and antihypotensive properties of 2-amino-2-thiazoline analogues with enhanced lipophilicity”, Mendeleev Commun., 28:4 (2018), 390–392
Svetlana Blokhina, Angelica Sharapova, Marina Ol'khovich, Tatyana Volkova, German Perlovich, Alexey N. Proshin, “Sublimation enthalpy of 1,3-thiazine structural analogues: Experimental determination and estimation based on structural clusterization”, Thermochimica Acta, 656 (2017), 10
Svetlana V. Blokhina, Angelica V. Sharapova, Marina V. Ol'khovich, Tatyana V. Volkova, Alexey N. Proshin, German L. Perlovich, “Thermodynamic Aspects of Solubility and Solvation of Bioactive Bicyclic Derivatives in Organic Solvents”, J. Chem. Eng. Data, 62:12 (2017), 4288
Svetlana V. Blokhina, Marina V. Ol'khovich, Angelica V. Sharapova, Tatyana V. Volkova, Alexey N. Proshin, German L. Perlovich, “Effect of the structure, solid state and lipophilicity on the solubility of novel bicyclic derivatives”, The Journal of Chemical Thermodynamics, 78 (2014), 152
Svetlana V. Blokhina, Marina V. Ol'khovich, Angelica V. Sharapova, German L. Perlovich, Alexey N. Proshin, “Vapor pressures and sublimation enthalpies of novel bicyclic heterocycle derivatives”, The Journal of Chemical Thermodynamics, 69 (2014), 107
Artem O. Surov, Alexey N. Proshin, German L. Perlovich, “Crystal structure analysis and sublimation thermodynamics of bicyclo derivatives of a neuroprotector family”, Acta Crystallogr B Struct Sci Cryst Eng Mater, 70:1 (2014), 47
D. V. Shishov, E. V. Nurieva, N. S. Zefirov, A. V. Mamaeva, O. N. Zefirova, “Synthesis of 5-hydroxy-4-methoxytricyclo[7.3.1.02,7]trideca-2,4,6-trien- 8-one – precursor of putative bioisosteric colchicine analogues”, Mendeleev Commun., 24:6 (2014), 370–371
E. D. Plotnikova, E. V. Nurieva, D. I. Peregud, M. V. Onufriev, N. V. Gulyaeva, V. M. Makarchuk, M. V. Filimonova, N. S. Zefirov, O. N. Zefirova, “Molecular modeling, X-ray diffraction analysis, and the study of iNOS inhibitor activity of 3-imino-2,4-diazabicyclo[3.3.1]nonan-1-ol hydrochloride”, Russ J Org Chem, 49:8 (2013), 1108
O. N. Zefirova, N. S. Zefirov, “Targeted application of bridged fragments in the design of physiologically active compounds”, Russ Chem Bull, 62:2 (2013), 325
O. N. Zefirova, E. D. Plotnikova, E. V. Nurieva, D. I. Peregud, M. V. Onufriev, N. V. Gulyaeva, “Synthesis of 2-thia-4-azabicyclo[3.3.1]non-3-en-3-amine – bridged nitric oxide synthase inhibitor with enhanced lipophilicity”, Mendeleev Commun., 23:2 (2013), 76–77
Olga N. Zefirova, Evgeniya V. Nurieva, Vladimir I. Chupakhin, Irina S. Semenova, Danil I. Peregud, Mikhail V. Onufriev, Natalia V. Gulyaeva, “ChemInform Abstract: Design, Synthesis and Biotest of a Bicyclo[3.3.1]nonane Analogue (V) of 2‐Amino‐5,6‐dihydro‐4H‐1,3‐thiazine.”, ChemInform, 42:13 (2011)
O. N. Zefirova, N. N. Moiseeva, E. V. Nurieva, T. P. Trofimova, A. N. Proshin, Yu. L. Slovokhotov, “Molecular and crystal structures of hetero-analogues of bicyclo[3.3.1]nonane with nitrogen and sulfur atoms”, Mendeleev Commun., 21:5 (2011), 247–249
O. N. Zefirova, I. S. Raguzin, V. V. Gogol, E. V. Nurieva, M. S. Belenikin, “Phosphates of bridgehead alcohols as putative inositol monophosphatase inhibitors: molecular design and synthetic approach”, Mendeleev Commun., 21:5 (2011), 242–244
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