Аннотация:
Benzylphosphonates of 5’-norcarbocyclic analogue of 2’,3’-dideoxy-2’,3’-didehydrouridine and its N3-benzyl derivatives with different substituents at the phosphorus atom were designed and synthesized in attempt to improve solubility of potential non-nucleoside reverse transcriptase inhibitor. Solubility of the most hydrophilic representative was 400 mg in 100 ml of 1% DMSO solution in water. The target phosphonates were examined against HIV-1 reverse transcriptase with KI for all compounds being higher than 100 μM.
Тип публикации:
Статья
Язык публикации: английский
Образец цитирования:
E. S. Matyugina, V. T. Valuev-Elliston, A. O. Chizhov, S. N. Kochetkov, A. L. Khandazhinskaya, “HIV-1 non-nucleoside reverse transcriptase inhibitors: incorporation of benzylphosphonate moiety for solubility improvement”, Mendeleev Commun., 26:2 (2016), 114–116
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc2128
https://www.mathnet.ru/rus/mendc/v26/i2/p114
Эта публикация цитируется в следующих 3 статьяx:
S. D. Negrya, M. V. Jasko, D. A. Makarov, I. L. Karpenko, P. N. Solyev, V. O. Chekhov, O. V. Efremenkova, B. F. Vasilieva, T. A. Efimenko, S. N. Kochetkov, L. A. Alexandrova, “Oligoglycol carbonate prodrugs of 5-modified 2'-deoxyuridines: synthesis and antibacterial activity”, Mendeleev Commun., 32:4 (2022), 433–435
L. I. Vagapova, J. K. Voronina, V. V. Syakaev, A. R. Burilov, A. R. Garyfzyanov, M. A. Pudovik, “Synthesis and structure of new 2-aryl-substituted pyrrolidines containing phosphine oxide group”, Mendeleev Commun., 28:4 (2018), 398–400
M. S. Gaman, E. S. Matyugina, M. S. Novikov, D. A. Babkov, P. N. Solyev, S. N. Kochetkov, A. L. Khandazhinskaya, “New benzophenone phosphonate derivatives”, Mendeleev Commun., 27:4 (2017), 346–348
Обратная связь: