Synthesis and antimycobacterial activity of novel purin-6-yl and 2-aminopurin-6-yl conjugates with (S)-aspartic and (S)-glutamic acids

Novel purine and 2-aminopurine conjugates containing fragments of (S)-aspartic and (S)-glutamic acids with free α-functional groups attached via a 1,2-ethylenediamine linker at 6-position of the purine core, as well as their analogues with N⁹-(2-hydroxyethoxy)methyl substituent have been synthesized. Among the conjugates obtained, compounds exhibiting a significant antimycobacterial activity have been found.