Аннотация:
A low-toxic ternary complex composed of anionic liposomes, cationic polylysine and slightly negative micelles from a polylactide– polyethylene glycol diblock copolymer is described. Liposomes with the encapsulated antitumor antibiotic Doxorubicin (Dox) retain their integrity after incorporation into the ternary complex. The incubation of cells with the Dox-loaded ternary complex leads to its penetration into the cells, the release of Dox from liposomes and predominant drug accumulation in cell nuclei. The ternary complex degrades to nanoparticles in the presence of proteolytic enzymes to produce low-toxic digestion products.
Образец цитирования:
A. A. Yaroslavov, A. A. Efimova, G. N. Rudenskaya, N. S. Melik-Nubarov, I. D. Grozdova, A. A. Ezhov, S. N. Chvalun, A. I. Kulebyakina, E. V. Kuznetsova, “An electrostatic conjugate composed of liposomes, polylysine and a polylactide micelle: a biodegradability–cytotoxicity relationship”, Mendeleev Commun., 27:3 (2017), 299–301
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc1975
https://www.mathnet.ru/rus/mendc/v27/i3/p299
Эта публикация цитируется в следующих 8 статьяx:
Ekaterina V. Kuznetsova, Nikita G. Sedush, Yulia A. Puchkova, Sergei V. Aleshin, Evgeny V. Yastremsky, Alexey A. Nazarov, Sergei N. Chvalun, “Highly Stable Docetaxel-Loaded Nanoparticles Based on Poly(D,L-lactide)-b-Poly(ethylene glycol) for Cancer Treatment: Preparation, Characterization, and In Vitro Cytotoxicity Studies”, Polymers, 15:10 (2023), 2296
A.A. Yaroslavov, A.A. Efimova, E.A. Krasnikov, K.S. Trosheva, A.S. Popov, N.S. Melik-Nubarov, G.G. Krivtsov, “Chitosan-based multi-liposomal complexes: Synthesis, biodegradability and cytotoxicity”, International Journal of Biological Macromolecules, 177 (2021), 455
A. A. Efimova, A. S. Popov, G. G. Krivtsov, “Anionic Liposomes in Contact with Cationic Chitosan Particles”, Russ J Gen Chem, 90:11 (2020), 2156
Olga A. Novoskoltseva, Oxana O. Ryabaya, Natalia V. Pozdniakova, Alexander A. Yaroslavov, “Low-toxic multi-liposomal containers for encapsulation of bioactive compounds”, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 603 (2020), 125282
Irina Grozdova, Nikolay Melik-Nubarov, Anna Efimova, Alexander Ezhov, George Krivtsov, Ekaterina Litmanovich, Alexander Yaroslavov, “Intracellular delivery of drugs by chitosan-based multi-liposomal complexes”, Colloids and Surfaces B: Biointerfaces, 193 (2020), 111062
A. A. Efimova, K. S. Trosheva, E. A. Krasnikov, G. G. Krivtsov, A. A. Yaroslavov, “Complexes of Anionic Cholesterol-Containing Liposomes and Cationic Chitosan Microparticles”, Polym. Sci. Ser. A, 61:6 (2019), 737
D. V. Pryazhnikov, O. O. Efanova, I. V. Kubrakova, “Cerasomes containing magnetic nanoparticles: synthesis and gel-filtration chromatographic characterization”, Mendeleev Commun., 29:2 (2019), 226–228
A. A. Yaroslavov, A. A. Efimova, F. D. Mulashkin, G. N. Rudenskaya, G. G. Krivtsov, “Biodegradable liposome–chitosan complexes: enzyme-mediated release of encapsulated substances”, Mendeleev Commun., 28:2 (2018), 140–142
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