Аннотация:
The effective and regioselective synthesis of new (2-hydrazinylthiazol-4-yl)furoxan hydrobromides based on the condensation of (bromoacetyl)furoxans with thiosemicarbazide has been developed. The cytotoxic activity of their derivatives (with hydrazone, 4-thiazolo[2.3-c][1,2,4]triazole or pyrrole moieties) against two human cancer cell lines (A549, HCT116) was tested and several structures revealed moderate cytotoxic activity.
Образец цитирования:
A. S. Kulikov, M. A. Epishina, A. I. Churakov, L. V. Anikina, L. L. Fershtat, N. N. Makhova, “Regioselective synthesis, structural diversification and cytotoxic activity of (thiazol-4-yl)furoxans”, Mendeleev Commun., 28:6 (2018), 623–625
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc1857
https://www.mathnet.ru/rus/mendc/v28/i6/p623
Эта публикация цитируется в следующих 14 статьяx:
E. E. Vinogradova, A. A. Larin, G. A. Gazieva, “Synthesis of hybrid molecules based on thioglycolurils and 1,2,5-oxadiazoles via the Eschenmoser sulfide contraction”, Mendeleev Commun., 34:1 (2024), 122–125
S. B. Kalashnikov, A. S. Vinogradov, I. Yu. Bagryanskaya, T. V. Mezhenkova, “Synthesis of 5-methyl-4-polyfluoroaryl-1,3-thiazol-2-amines”, Mendeleev Commun., 34:2 (2024), 277–278
Yu‐Min Shi, Jun Wang, Heng Yan, “The current scenario of furoxan hybrids with anticancer potential”, Journal of Heterocyclic Chem, 60:10 (2023), 1651
M. A. Epishina, A. S. Kulikov, L. L. Fershtat, “Synthesis of Aromatic Bishydrazones: New Facets of a Known Reaction”, Russ J Gen Chem, 93:S2 (2023), S444
M. A. Epishina, A. S. Kulikov, L. L. Fershtat, “Synthesis of aromatic bishydrazones: new facets of a known reaction”, Žurnal obŝej himii, 93:11 (2023), 1643
Nina N. Makhova, Leonid L. Fershtat, Comprehensive Heterocyclic Chemistry IV, 2022, 190
Leonid L. Fershtat, Egor S. Zhilin, “Recent Advances in the Synthesis and Biomedical Applications of Heterocyclic NO-Donors”, Molecules, 26:18 (2021), 5705
Fedor E. Teslenko, Artem I. Churakov, Alexander A. Larin, Ivan V. Ananyev, Leonid L. Fershtat, Nina N. Makhova, “Route to 1,2,4- and 1,2,5-oxadiazole ring assemblies via a one-pot condensation/oxidation protocol”, Tetrahedron Letters, 61:13 (2020), 151678
Egor S. Zhilin, Michael S. Polkovnichenko, Ivan V. Ananyev, Leonid L. Fershtat, Nina N. Makhova, “Novel Arylazo‐1,2,5‐oxadiazole Photoswitches: Synthesis, Photoisomerization and Nitric Oxide Releasing Properties”, ChemPhotoChem, 4:12 (2020), 5346
Н. Н. Махова, Л. И. Беленький, Г. А. Газиева, И. Л. Далингер, Л. С. Константинова, В. В. Кузнецов, А. Н. Кравченко, М. М. Краюшкин, О. А. Ракитин, А. М. Старосотников, Л. Л. Ферштат, С. А. Шевелев, В. З. Ширинян, В. Н. Яровенко, “Прогресс в химии азот-, кислород- и серасодержащих гетероциклических систем”, Усп. хим., 89:1 (2020), 55–124; N. N. Makhova, L. I. Belen'kii, G. A. Gazieva, I. L. Dalinger, L. S. Konstantinova, V. V. Kuznetsov, A. N. Kravchenko, M. M. Krayushkin, O. A. Rakitin, A. M. Starosotnikov, L. L. Fershtat, S. A. Shevelev, V. Z. Shirinian, V. N. Yarovenko, “Progress in the chemistry of nitrogen-, oxygen- and sulfur-containing heterocyclic systems”, Russian Chem. Reviews, 89:1 (2020), 55–124
Egor S. Zhilin, Leonid L. Fershtat, Dmitry M. Bystrov, Alexander S. Kulikov, Artem O. Dmitrienko, Ivan V. Ananyev, Nina N. Makhova, “Renaissance of 1,2,5‐Oxadiazolyl Diazonium Salts: Synthesis and Reactivity”, Eur J Org Chem, 2019:26 (2019), 4248
Egor S. Zhilin, Dmitry M. Bystrov, Ivan V. Ananyev, Leonid L. Fershtat, Nina N. Makhova, “Straightforward Access to the Nitric Oxide Donor Azasydnone Scaffold by Cascade Reactions of Amines”, Chemistry A European J, 25:63 (2019), 14284
S. A. Pukhov, L. A. Anikina, A. A. Larin, L. L. Fershtat, A. S. Kulikov, N. N. Makhova, “Hetarylfuroxans: cytotoxic effect and induction of apoptosis in chronic myeloid leukemia K562 cells”, Russ Chem Bull, 68:1 (2019), 158
M. A. Epishina, A. S. Kulikov, L. L. Fershtat, I. V. Ananyev, N. N. Makhova, “Synthesis of new pharmacologically oriented heterocyclic ensembles, [2-(1H-pyrazol-1-yl)thiazol-4-yl]furoxans”, Mendeleev Commun., 29:3 (2019), 288–291
Обратная связь: