aDepartment of Organic Chemistry, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China bBenxi Institute of Pharmaceutical Research, Shenyang Pharmaceutical University, Benxi, China cState Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, China
Аннотация:
A new 5′-dimethoxytrityl N6-alkynylated 2′-deoxyadenosine phosphoramidite has been designed and synthesized from 2′-deoxyadenosine. The applicability of this building block for the production of alkyne-modified oligodeoxynucleotide has been demonstrated. This allows one to introduce various labels into DNA using the click reaction.
Образец цитирования:
Sh. Wang, F. Liu, J. Fang, Ya. Li, J. Liu, M. Liu, “Synthesis of a new alkynylated deoxyadenosine phosphoramidite for the click reaction-mediated DNA labeling”, Mendeleev Commun., 29:5 (2019), 503–505
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