Synthesis, study of biological activity, and hemocompatibility of potential antitumor compounds of thiazolopyrimidinium systems

Four novel antitumor agents, representatives of (E)-5-(4- dimethylaminostyryl)-7-methylthiazolo[3,2-a]pyrimidin-4-ium salts, were synthesized by sequential reactions of the corresponding aminothiazoles with acetylacetone and 4-dimethylaminobenzaldehyde. Cytotoxicity was assessed on five different cell lines (HeLa, PANC-1, A549, MCF-7, and ECV304). The results indicate that the salts have significant potential for further development as anticancer drugs.