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Эта публикация цитируется в 7 научных статьях (всего в 7 статьях)
Synthesis of an allosteric modulator of ionotropic glutamate receptors
M. I. Lavrovab, O. V. Stroganovcd, V. L. Zamoyskib, V. V. Grigorievab, M. E. Zapolskiyd, S. V. Sysolyatine, V. V. Malykhine, V. N. Surmacheve, V. A. Palyulinab
a Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
b Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation
c N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
d QM Pharma LLC, Skolkovo Innovation Center, Moscow, Russian Federation
e Institute for Problems of Chemical & Energetic Technologies, Siberian Branch of the Russian Academy of Sciences, Biysk, Russian Federation
Аннотация:
Synthesis of 6-[4-methoxy-3-(pyrrolidin-1-ylmethyl)benzyl]-1,11-dimethyl-3,6,9-triazatricyclo[7.3.1.13,11]tetradecane-4,8,12-trione has been carried out and optimized. In vitro studies using electrophysiological patch clamp technique
have revealed a negative effect of this compound on kainateinduced currents in Purkinje neurons in a wide range of concentrations from 10–11 to 10–6 m.
Ключевые слова:
3,7-diazabicyclo[3.3.1]nonane, AMPA receptor, negative allosteric modulator, NAM, patch clamp.
Образцы ссылок на эту страницу:
https://www.mathnet.ru/rus/mendc1132
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