New antitumor hybrid materials based on PtIV organic complex and polymer nanoparticles consisting of N-vinylpyrrolidone and (di)methacrylates

New cis-bis[N-(2-nitroxyethyl)isonicotinamide-N]platinum(iv) tetrachloride hybrid materials were obtained via its solubilization by nanoparticles of N-vinylpyrrolidone copolymer with dimethacrylates and characterized. The materials containing 2% of PtIV complex cause a cytotoxic effect on the tumor A-172 cells; IC50 values were ca. 106μm after incubation for 48h.